Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Combination of a calcium antagonist verapamil with an angiotensin converting enzyme inhibitor, trandolapril in experimental myocardial ischemia and reperfusion: Antiarrhythmic and hemodynamic effects of chronic oral pretreatment
Autore:
Muller, CA; Opie, LH; Pineda, CA; McCarthy, J; Kraljevic, V;
Indirizzi:
Univthape Town, Heart Res Grp, MRC, Cape Heart Ctr, ZA-7700 Rondebosch, Sou Univ Cape Town Rondebosch South Africa ZA-7700 , ZA-7700 Rondebosch, Sou Natl Accelerator Ctr, Cape Town, South Africa Natl Accelerator Ctr Cape Town South Africa tr, Cape Town, South Africa
Titolo Testata:
CARDIOVASCULAR DRUGS AND THERAPY
fascicolo: 5, volume: 12, anno: 1998,
pagine: 449 - 455
SICI:
0920-3206(199810)12:5<449:COACAV>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT RELAXATION; CYCLIC ADENOSINE-MONOPHOSPHATE; VENTRICULAR-FIBRILLATION; ANESTHETIZED DOGS; RAT-HEART; ARRHYTHMIAS; VULNERABILITY; INFARCTION; CAPTOPRIL; PIG;
Keywords:
acute myocardial ischemia; reperfusion; calcium antagonist; ACE inhibitor; verapamil; trandolapril; myocardial blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, CA Univfrica Town, Sch Med, Heart Res Unit, Observ, ZA-7925 Cape Town, South A Univ Cape Town Cape Town South Africa ZA-7925 e Town, South A
Citazione:
C.A. Muller et al., "Combination of a calcium antagonist verapamil with an angiotensin converting enzyme inhibitor, trandolapril in experimental myocardial ischemia and reperfusion: Antiarrhythmic and hemodynamic effects of chronic oral pretreatment", CARDIO DRUG, 12(5), 1998, pp. 449-455

Abstract

The combination of a calcium antagonist with an angiotensin-converting enzyme (ACE) inhibitor is increasingly used in the therapy of hypertension, but there are no experimental data supporting the use of this combination in acute myocardial ischemia and reperfusion. We tested the effects of oral pretreatment in a pig model, paying special attention to arrhythmias and adverse hemodynamic effects. Pigs received verapamil 240 mg + trandolapril 4 mg, verapamil 240 mg, or placebo orally once daily for 10 days, after which acoronary artery was ligated for 20 minutes and then allowed to reperfuse. The ventricular fibrillation threshold (VFT) was measured during ischemia to assess the vulnerability of the heart to ventricular fibrillation, whereas spontaneous tachyarrhythmias were monitored during reperfusion. Regional left ventricular (LV) blood flow was measured with radioactive microspheres. During the ischemic-period, both the combination of verapamil plus trandolapril, and verapamil alone, prevented a fall in the VFT, indicating antiarrhythmic activity. The combination maintained LV contractile activity and cardiac output (CO) at preligation levels, whereas verapamil alone decreasedcardiac output. During reperfusion, verapamil plus trandolapril prevented spontaneous ventricular tachyarrhythmias and increased blood flow in the reperfused zone. In contrast, verapamil was not antiarrhythmic and decreased CO. Thus the addition of the ACE inhibitor trandolapril to the calcium antagonist verapamil resulted in antiarrhythmic activity during ischemia and reperfusion, and produced a better hemodynamic profile.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:34:48