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Titolo:
Different cytokines modulate ubiquitin gene expression in rat skeletal muscle
Autore:
Llovera, M; Carbo, N; Lopez-Soriano, J; Garcia-Martinez, C; Busquets, S; Alvarez, B; Agell, N; Costelli, P; Lopez-Soriano, FJ; Celada, A; Argiles, JM;
Indirizzi:
Univiol,celona, Unitat Bioquim & Biol Mol B, Dept Bioquim & Biol Mol, Fac B Univ Barcelona Barcelona Spain 08071 l B, Dept Bioquim & Biol Mol, Fac B Univ Barcelona, Fac Med, Dept Cellular Biol, Barcelona 7, Spain Univ Barcelona Barcelona Spain 7 Dept Cellular Biol, Barcelona 7, Spain Univ Turin, Dipartimento Med & Oncol Sperimentale, Turin, Italy Univ Turin Turin Italy artimento Med & Oncol Sperimentale, Turin, Italy Univ Barcelona, Fac Biol, Dept Fisiol, Barcelona, Spain Univ Barcelona Barcelona Spain Fac Biol, Dept Fisiol, Barcelona, Spain
Titolo Testata:
CANCER LETTERS
fascicolo: 1, volume: 133, anno: 1998,
pagine: 83 - 87
SICI:
0304-3835(19981113)133:1<83:DCMUGE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; FACTOR-ALPHA CACHECTIN; CANCER CACHEXIA; PROTEIN BREAKDOWN; COLON-26 ADENOCARCINOMA; PROTEOLYTIC PATHWAY; NUDE-MICE; INTERLEUKIN-6; METABOLISM; TURNOVER;
Keywords:
TNF-alpha; IL-1; IL-6; IFN-gamma; LIF; cancer cachexia; muscle waste;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Argiles, JM Univiol,celona, Unitat Bioquim & Biol Mol B, Dept Bioquim & Biol Mol, Fac B Univ Barcelona Diagonal 645 Barcelona Spain 08071 Mol, Fac B
Citazione:
M. Llovera et al., "Different cytokines modulate ubiquitin gene expression in rat skeletal muscle", CANCER LETT, 133(1), 1998, pp. 83-87

Abstract

Intravenous administration of different cytokines caused important changesin the expression of ubiquitin genes in skeletal muscle. Tumour necrosis factor-alpha caused a 2.2- and 1.9-fold increase in the expression of the 2.4 and 1.2 kb transcripts, respectively. Administration of interferon-gamma also caused a 2.2- and 1.8-fold increase in the 2.4 and 1.2 kb transcripts,respectively. While administration of leukaemia inhibitory factor and interleukin-6 resulted in no changes in ubiquitin gene expression, interleukin-l administration also caused an increase in both ubiquitin gene transcripts(2.8- and 1.9-fold for the 2.4 and 1.2 kb transcripts, respectively). The results suggest that some of the cytokine effects on the ubiquitin system gene expression could be related to the enhanced skeletal muscle proteolysisfound during cancer cachexia and other pathological states. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:36:19