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Titolo:
Procalcitonin - a sepsis parameter in severe burn injuries
Autore:
von Heimburg, D; Stieghorst, W; Khorram-Sefat, R; Pallua, N;
Indirizzi:
Rheing,estfal TH Aachen Hosp, Dept Plast & Reconstruct Surg Hand & Burn Sur Rhein Westfal TH Aachen Hosp Aachen Germany struct Surg Hand & Burn Sur
Titolo Testata:
BURNS
fascicolo: 8, volume: 24, anno: 1998,
pagine: 745 - 750
SICI:
0305-4179(199812)24:8<745:P-ASPI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; SERUM PROCALCITONIN; INHALATION INJURY; THERMAL-INJURY; TNF-ALPHA; INFECTION;
Keywords:
burn; inhalation injury; procalcitonin; score; sepsis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: von Heimburg, D Rheing,estfal TH Aachen Hosp, Dept Plast & Reconstruct Surg Hand & Burn Sur Rhein Westfal TH Aachen Hosp Aachen Germany & Burn Sur
Citazione:
D. von Heimburg et al., "Procalcitonin - a sepsis parameter in severe burn injuries", BURNS, 24(8), 1998, pp. 745-750

Abstract

Procalcitonin (PCT) levels increase in patients with systemic infections; the highest levels have been found in sepsis. This study tested whether plasma procalcitonin level was related to sepsis, CRP, burn size, inhalation injury or mortality in severely burned patients over the entire clinical course. In 27 patients with 51 (20-91)% TBSA, PCT was measured three times weekly from admission over the entire course of stay in a single ICU. Daily scoring by the "Baltimore Sepsis-Scale" was performed. The patients were assignedto three groups depending on the clinical course and outcome: A = no septic complications, B = septic complications-survivors, C = septic complications-non-survivors. PCT levels were elevated slightly at admission (mean 2.1 ng/ml) except in three patients who suffered electrical burns (mean 15.7 ng/ml). PCT peak levels correlated well with the Scoring values (r = 0.84) while CRP did not (r = 0.64). Peak PCT levels were significantly higher (p < 0.005) in septic patients (B and C) who averaged 49.8 +/- 76.9 ng/ml, than in non-septic patients (A) who averaged peak levels of 2.3 +/- 3.7 ng/ml. The highest PCT levels were found immediately before death (86.8 +/- 97 ng/ml). Seven patients had an inhalation injury III degrees. In these patients at 24 h postburn,there was no relationship between PCT levels and inhalation injury but during the later days postburn there were significant differences in PCT levels in patients with Versus without inhalation injury. All patients with inhalation injury III degrees developed septic complications. There was no positive correlation between the PCT-admission-levels and theTBSA, but there was a positive correlation between the TBSA and the mean peak PCT levels during the later days postburn (r = 0.73; p < 0.05). The cut-off Value of 3 ng/ml we found reliable to indicate severe bacterial or fungal infection. PCT values over 10 ng/ml increasing over the following days were found only in life-threatening situations due to systemic infections. The individual course of PCT in one patient is more important than absolutevalues. PCT presented in this study as a useful diagnostic parameter in severely burned patients. (C) 1998 Elsevier Science Ltd for ISBI. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:46:43