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Titolo:
Electron microscopy and capillaroscopically guided nailfold biopsy in connective tissue diseases: Detection of ultrastructural changes of the microcirculatory vessels
Autore:
von Bierbrauer, A; Barth, P; Willert, J; Baerwald, C; Mennel, HD; Schmidt, JA;
Indirizzi:
Univ Marburg, Dept Internal Med, D-35032 Marburg, Germany Univ Marburg Marburg Germany D-35032 ernal Med, D-35032 Marburg, Germany Univ Marburg, Dept Pathol, D-35032 Marburg, Germany Univ Marburg MarburgGermany D-35032 pt Pathol, D-35032 Marburg, Germany
Titolo Testata:
BRITISH JOURNAL OF RHEUMATOLOGY
fascicolo: 12, volume: 37, anno: 1998,
pagine: 1272 - 1278
SICI:
0263-7103(199812)37:12<1272:EMACGN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE SYSTEMIC-SCLEROSIS; INVIVO CAPILLARY MICROSCOPY; LUPUS-ERYTHEMATOSUS; RAYNAUDS-PHENOMENON; VASCULAR-DISEASE; MAST-CELLS; T-CELLS; SCLERODERMA; DISORDERS; FIBROBLASTS;
Keywords:
electron microscopy; histology; biopsy; microcirculation; connective tissue diseases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: von Bierbrauer, A Univ Marburg Klinikum, Zentrum Innere Med, Abt Med Poliklin, Baldinger Str, Univ Marburg Klinikum Baldinger Str Marburg Germany D-35033
Citazione:
A. von Bierbrauer et al., "Electron microscopy and capillaroscopically guided nailfold biopsy in connective tissue diseases: Detection of ultrastructural changes of the microcirculatory vessels", BR J RHEUM, 37(12), 1998, pp. 1272-1278

Abstract

The aims of the study were to describe and compare the frequency and nature of histologically detectable microvascular lesions in patients with various connective tissue diseases (CTD). An electron microscopic examination ofspecimens obtained by the technique of capillaroscopically guided nailfoldbiopsy was performed in 52 patients with CTD [nine systemic lupus erythematosus (SLE), eight mixed CTD, 18 scleroderma, 17 undifferentiated CTD] and 27 controls. The microvascular changes most frequently observed by electronmicroscopy were multilayering of the basal lamina (similar to 70% of the CTD patients), an increased amount of perivascular connective tissue, perivascular oedema formation, and an increased number of perivascular fibroblasts and mast cells (each in 30-37% of the CTD patients). In contrast, no particular histopathological feature was found in >25% of the controls, multilayering (22.6%) being the most frequently observed. Comparing the different conditions studied, there were distinct differences in the frequency and nature of the histologically observed microvascular changes. In particular, SLE seems to be based on a separable type of vasculopathy consisting of significantly less frequent microvascular abnormalities. In conclusion, ultrastructural abnormalities of the microvascular system are a frequent finding in CTD. Electron microscopic examination of specimens obtained by capillaroscopically guided nailfold biopsy is able to disclose histopathological differences between defined entities. Therefore, this approach may be a useful tool to gain further insights into potentially separable aetiopathological mechanisms of the various types of CTD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:25:28