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Titolo:
Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance
Autore:
Ackermann, J; Meidlinger, P; Zojer, N; Gisslinger, H; Ludwig, H; Huber, H; Drach, J;
Indirizzi:
Univ Vienna, Dept Internal Med 1, Div Clin Oncol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Div Clin Oncol, A-1090 Vienna, Austria Univ Vienna, Div Haematol & haemostaseol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 & haemostaseol, A-1090 Vienna, Austria Wilhelminenspital, Dept Internal Med Oncol 1, Vienna, Austria Wilhelminenspital Vienna Austria Internal Med Oncol 1, Vienna, Austria
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 4, volume: 103, anno: 1998,
pagine: 1161 - 1163
SICI:
0007-1048(199812)103:4<1161:AOPDIB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; UNDETERMINED SIGNIFICANCE; DIAGNOSIS; GENES;
Keywords:
interphase FISH; MGUS; p53 gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Drach, J Univ-1090na, Dept Internal Med 1, Div Clin Oncol, Wahringer Gurtel 18-20, A Univ Vienna Wahringer Gurtel 18-20 Vienna Austria A-1090 8-20, A
Citazione:
J. Ackermann et al., "Absence of p53 deletions in bone marrow plasma cells of patients with monoclonal gammopathy of undedetermined significance", BR J HAEM, 103(4), 1998, pp. 1161-1163

Abstract

We have recently shown that presence of a p53 deletion in multiple myleomais an independent predictor for short survival. We therefore investigated whether or not this chromosomal abnormality can be identified in patients with monoclonal gammopathy of undetermined significance (MGUS), Using a triple staining method combining staining for cytoplasmic immunoglobulins and fluorescence in situ hybridization (FISH) with chromosome 17-centromere and p53-gene specific probes, we studied plasma cells from 15 patients with MGUS. In all patients, concordant signal numbers with both probes were obtained (including one patient with trisomy 17), indicating that allelic loss of p53 does not occur in MGUS.

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Documento generato il 30/10/20 alle ore 09:40:30