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Titolo:
Lesions of the nucleus basalis magnocellularis do not impair prepulse inhibition and latent inhibition of fear-potentiated startle in the rat
Autore:
Schauz, C; Koch, M;
Indirizzi:
Univ Tubingen, D-72076 Tubingen, Germany Univ Tubingen Tubingen Germany D-72076 bingen, D-72076 Tubingen, Germany
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 815, anno: 1999,
pagine: 98 - 105
SICI:
0006-8993(19990102)815:1<98:LOTNBM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-INDUCED LESIONS; METHYL-D-ASPARTATE; ACOUSTIC STARTLE; CHOLINE-ACETYLTRANSFERASE; CONDITIONED-STIMULUS; EXCITOTOXIC LESIONS; QUISQUALIC ACID; FOREBRAIN; ATTENTION; AMYGDALA;
Keywords:
acoustic startle response; fear-potentiated startle; latent inhibition; nucleus basalis magnocellularis; prepulse inhibition; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Schauz, C Univ Tubingen, Morgenstelle 28, D-72076 Tubingen, Germany Univ Tubingen Morgenstelle 28 Tubingen Germany D-72076 Germany
Citazione:
C. Schauz e M. Koch, "Lesions of the nucleus basalis magnocellularis do not impair prepulse inhibition and latent inhibition of fear-potentiated startle in the rat", BRAIN RES, 815(1), 1999, pp. 98-105

Abstract

The present study tested if lesions of the nucleus basalis magnocellularis(NBM) affect prepulse inhibition (PPI) of the acoustic startle response and latent inhibition (LI) of fear-potentiated startle. The NBM is known to play an important role in learning and memory. Recently, the interest of research focused on its role in attentional and response selection processes. We here tested the effect of excitotoxic NBM-lesions on PPI, a phenomenon of sensorimotor Eating that occurs at early stages of information processing. We also assessed the lesion effects on LI, a phenomenon of reduced conditioning after stimulus preexposure that can be used to measure selective attention. Bilateral infusions into the NBM of 80 nmol of quinolinic acid markedly reduced the number of choline acetyltransferase immunopositive neuronsin the NBM and lead to a pronounced reduction of acetylcholine esterase inthe cortex and the amygdala. However, no effects on PPI, fear-conditioning, or LI of fear-potentiated startle were found. Therefore, we conclude thatthere is no NBM-driven attentional or response selection process involved in PPI. Furthermore, the simple association learning in the classical conditioning paradigm used for fear-potentiated startle or LI is unaffected by NBM-lesions. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:36:38