Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The effects of pharmacological doses of 2-deoxyglucose on cerebral blood flow in healthy volunteers
Autore:
Elman, I; Sokoloff, L; Adler, CM; Weisenfeld, N; Breier, A;
Indirizzi:
NIMH, Expt Therapeut Branch, NIH, Bethesda, MD 20892 USA NIMH Bethesda MDUSA 20892 Therapeut Branch, NIH, Bethesda, MD 20892 USA NIMH, Cerebral Metab Lab, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 erebral Metab Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 815, anno: 1999,
pagine: 243 - 249
SICI:
0006-8993(19990109)815:2<243:TEOPDO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-INDUCED HYPOGLYCEMIA; AUTOMATED ALGORITHM; METABOLIC STRESS; GLUCOSE-INFUSION; 2-DEOXY-D-GLUCOSE; CATECHOLAMINES; HYPOTHERMIA; TOMOGRAPHY; MECHANISMS; RECOVERY;
Keywords:
glucose deprivation; PET; mean arterial pressure; hypothalamus; body temperature;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Elman, I Harvardoston, Massachusetts Gen Hosp, Sch Med, W End House,16 Blossom St, B Harvard Univ W End House,16 Blossom St Boston MA USA 02114 St, B
Citazione:
I. Elman et al., "The effects of pharmacological doses of 2-deoxyglucose on cerebral blood flow in healthy volunteers", BRAIN RES, 815(2), 1999, pp. 243-249

Abstract

The effects of glucose deprivation on cerebral blood flow (CBF) have been extensively investigated during insulin-induced hypoglycemia in laboratory animals. Pharmacological doses of glucose analog, 2-deoxyglucose (2DG), is an alternative glucoprivic agent that in contrast to insulin, directly inhibits glycolysis and glucose utilization. Both glucoprivic conditions markedly increase CBF in laboratory animals. How 2DG affects CBF in humans is still undetermined. In the present study we have employed (H2O)-O-15 positron emission tomography (PET) to examine the effects of pharmacological doses of 2DG (40 mg/kg) on regional and global cerebral blood flow in 10 brain areas in 13 healthy volunteers. 2DG administration significantly raised regional CBF (rCBF) in the cingulate gyrus, sensorimotor cortex, superior temporal cortex, occipital cortex, basal ganglia, limbic system and hypothalamus. 2DG produced a trend towards elevated CBF in whole brain and frontal cortex, while no changes were observed in the corpus callosum and thalamus. In addition, 2DG significantly decreased body temperature and mean arterial pressure (MAP). Maximal percent changes in hypothalamic rCBF were significantlycorrelated with maximal changes in body temperature but not with MAP. These results indicate that cerebral glucoprivation produced by pharmacologicaldoses of 2DG is accompanied by widespread activation of cortical and subcortical blood now and that the blood flow changes in the hypothalamus may berelated to 2DG-induced hypothermia. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:26:22