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Titolo:
The effect of benzodiazepines and flumazenil on motor cortical excitability in the human brain
Autore:
Palmieri, MG; Iani, C; Scalise, A; Desiato, MT; Loberti, M; Telera, S; Caramia, MD;
Indirizzi:
Univme,ma Tor Vergata 2, OS Eugenio, Neurol Clin, Dept Neurosci, I-00144 Ro Univ Roma Tor Vergata 2 Rome Italy I-00144 in, Dept Neurosci, I-00144 Ro IRCCS S Lucia, Rome, Italy IRCCS S Lucia Rome ItalyIRCCS S Lucia, Rome, Italy
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 815, anno: 1999,
pagine: 192 - 199
SICI:
0006-8993(19990109)815:2<192:TEOBAF>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL MAGNETIC STIMULATION; GENERALIZED EPILEPSY; RECEPTOR; ANTAGONISTS; DISORDERS; DIAZEPAM;
Keywords:
transcranial magnetic stimulation; benzodiazepine; GABA; cortical excitability; MEP; drug abuse; idiopathic stupor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Caramia, MD Univmanesimor Vergata 2, OS Eugenio, Neurol Clin, Dept Neurosci, Piazzale U Univ Roma Tor Vergata 2 Piazzale Umanesimo 10 Rome Italy I-00144
Citazione:
M.G. Palmieri et al., "The effect of benzodiazepines and flumazenil on motor cortical excitability in the human brain", BRAIN RES, 815(2), 1999, pp. 192-199

Abstract

In the present study, the effects of benzodiazepines (diazepam) were evaluated in terms of cortical excitability changes, as tested with transcranialmagnetic simulation (TMS). In particular, analyzed were drug-induced changes regarding two selected parameters of TMS: (1) the cortical excitability threshold and (2) the silent period duration (SP). For this purpose, we evaluated the effects of long-term therapy with diazepam in the patients affected by anxiety disorders and the changes induced by single oral doses of diazepam in both healthy controls and patients. In addition, we tested cortical excitability changes in two 'extreme conditions' where a considerable concentration of serum benzodiazepine-like activity was reached, as represented by diazepam overdose and idiopathic recurrent stupor (IRS). In both groups of patients, a significant increment of motor threshold was found, whilein the overdose patients, the SP was also increased. The administration offlumazenil in these two conditions was followed by a prompt reversal effect, consisting of a return to normal cortical excitability parameters. The long-term usage of diazepam in patients with anxiety disorders is associatedwith significantly increased threshold: the increased value of these parameters was temporarily further enhanced by the administration of a single oral dose of diazepam, which, in normal control subjects, is not associated with changes of cortical excitability. The results of this study reveal thatdifferent physio-pathological conditions induced by the influence of benzodiazepine and its antagonist are reflected in excitability changes which attest to the involvement and modification of cortical GABAergic activity. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

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Documento generato il 08/04/20 alle ore 12:13:50