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Titolo:
Effects of systemic resiniferatoxin treatment on substance P mRNA in rat dorsal root ganglia and substance P receptor mRNA in the spinal dorsal horn
Autore:
Szallasi, A; Farkas-Szallasi, T; Tucker, JB; Lundberg, JM; Hokfelt, T; Krause, JE;
Indirizzi:
Karolinska Inst, Dept Pharmacol, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 acol, S-17177 Stockholm, Sweden Karolinska Inst, Dept Neurosci, S-17177 Stockholm, Sweden Karolinska InstStockholm Sweden S-17177 osci, S-17177 Stockholm, Sweden Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 & Neurobiol, St Louis, MO 63110 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 815, anno: 1999,
pagine: 177 - 184
SICI:
0006-8993(19990109)815:2<177:EOSRTO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SENSORY NEURONS; PRIMARY AFFERENT NEURONS; NERVE GROWTH-FACTOR; ULTRAPOTENT CAPSAICIN ANALOG; GENE-RELATED PEPTIDE; ADULT-RAT; SELECTIVE DEGENERATION; INTRAVESICAL RESINIFERATOXIN; MOLECULAR CHARACTERIZATION; NEONATAL CAPSAICIN;
Keywords:
resiniferatoxin; vanilloid receptor; desensitization to vanilloid; substance P expression; tachykinin NK-1 receptor expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Szallasi, A NCI, NIH, Bldg 37,Rm 3A01,9000 Rockville Pike, Bethesda, MD 20892 USA NCI Bldg 37,Rm 3A01,9000 Rockville Pike Bethesda MD USA 20892
Citazione:
A. Szallasi et al., "Effects of systemic resiniferatoxin treatment on substance P mRNA in rat dorsal root ganglia and substance P receptor mRNA in the spinal dorsal horn", BRAIN RES, 815(2), 1999, pp. 177-184

Abstract

Capsaicin depletes the sensory neuropeptide substance P (SP) in the rat due to a combination of neuron loss and decreased synthesis in the surviving cells. Resiniferatoxin (RTX) mimics most, but not all, capsaicin actions. In the present study, the effects of RTX (300 mu g/kg, s.c.) were examined on mRNA levels for SP and its receptor in the adult rat. The percentage of dorsal root ganglia (DRG) neuronal profiles showing an in situ hybridizationsignal for preprotachykinin mRNAs encoding SP was not altered following RTX treatment (up to 8 weeks), though the signal became perceptibly weaker. In accord, 2 weeks after RTX administration a 60% decrease was observed in the steady-state levels of SP-encoding mRNAs using Northern blot analysis, leaving the ratio of beta- and gamma-preprotachykinin mRNAs unchanged. No change was, however, observed in mRNA levels encoding tachykinins NK-1 receptors in the dorsal horn, the spinal targets for SP. The present findings suggest that RTX does not kill SP-positive DRG neurons, though it suppresses the synthesis of SP. Since RTX treatment does not alter NK-1 receptor expression, this reduced SP synthesis is likely to play a central role in the analgesic actions of RTX. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:17:00