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Titolo:
Endogenous nitric oxide in the rat pons promotes sleep
Autore:
Hars, B;
Indirizzi:
Univ05aris Sud, URA CNRS 1491, Lab Neurobiol Apprentissage & Memoire, F-914 Univ Paris Sud Orsay France F-91405 obiol Apprentissage & Memoire, F-914
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 816, anno: 1999,
pagine: 209 - 219
SICI:
0006-8993(19990116)816:1<209:ENOITR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDUNCULOPONTINE TEGMENTAL NUCLEUS; CENTRAL CHOLINERGIC SYSTEMS; PONTINE RETICULAR-FORMATION; EYE-MOVEMENT SLEEP; ACETYLCHOLINE-RELEASE; NADPH-DIAPHORASE; BRAIN-STEM; IN-VITRO; PONTOMESENCEPHALIC TEGMENTUM; AFFERENT CONNECTIONS;
Keywords:
nitric oxide; pedunculopontine tegmentum; cholinergic cell; sleep; wakefulness; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Hars, B Univ45,ris Sud, URA CNRS 1491, Lab Neurobiol Apprentissage & Memoire, Bat 4 Univ Paris Sud Bat 445 Orsay France F-91405 sage & Memoire, Bat 4
Citazione:
B. Hars, "Endogenous nitric oxide in the rat pons promotes sleep", BRAIN RES, 816(1), 1999, pp. 209-219

Abstract

Pontine cholinergic structures are known to play a key role in the regulation of vigilance states associated with desynchronised EEG, i.e., wakefulness and paradoxical sleep. As the cholinergic cells of these nuclei, the pedunculopontine tegmentum (PPT) and the laterodorsal tegmentum, are enriched with nitric oxide synthase (NOS), we tested the hypothesis that nitric oxide (NO) in the pens is implicated in wake and sleep regulation. For this reason, a NOS inhibitor, a NO precursor and a NO donor were injected in the PPT of rats. Vigilance states were recorded for 6 h following the injections. Quantification of vigilance states after drug injections were compared to those obtained in control conditions. It appeared that the NO donor had a slight effect on vigilance states, but the NOS inhibitor decreased sleep andinversely the NO precursor increased sleep. These results show for the first time in the rat that a NOS inhibitor, injected directly into the PPT, isable to reduce sleep and that a NO precursor had the opposite effect. Theysuggest that endogenous NO production in the PPT has a somnogenic effect. The participation of endogenous NO in vigilance regulation is discussed in light of the role attributed to pontine cholinergic system in wakefulness and sleep. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/11/20 alle ore 07:29:23