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Titolo:
Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor
Autore:
Rizvi, TA; Akunuru, S; de Courten-Myers, G; Switzer, RC; Nordlund, ML; Ratner, N;
Indirizzi:
Univ45267innati, Coll Med, Dept Cell Biol Neurobiol & Anat, Cincinnati, OHUniv Cincinnati Cincinnati OH USA 45267 Neurobiol & Anat, Cincinnati, OH Univ Cincinnati, Coll Med, Dept Pathol, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 Pathol, Cincinnati, OH 45267 USA Neurosci Assoc, Knoxville, TN 37922 USA Neurosci Assoc Knoxville TN USA 37922 osci Assoc, Knoxville, TN 37922 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 816, anno: 1999,
pagine: 111 - 123
SICI:
0006-8993(19990116)816:1<111:RAIBOM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLARY ACIDIC PROTEIN; REACTIVE ASTROCYTES; SCHWANN-CELLS; VONRECKLINGHAUSEN NEUROFIBROMATOSIS; ACADEMIC-PERFORMANCE; CONSENSUS STATEMENT; COGNITIVE FUNCTION; GENE-PRODUCT; WHITE MATTER; MR FINDINGS;
Keywords:
neurofibromatosis; NF1; astrocyte; gliosis; learning disability; ras; mouse; neurofibromin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Ratner, N Unive,incinnati, Coll Med, Dept Cell Biol Neurobiol & Anat, 231 Bethesda Av Univ Cincinnati 231 Bethesda Ave Cincinnati OH USA 45267 esda Av
Citazione:
T.A. Rizvi et al., "Region-specific astrogliosis in brains of mice heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor", BRAIN RES, 816(1), 1999, pp. 111-123

Abstract

Brains from human neurofibromatosis type I (NF1) patients show increased expression of glial fibrillary acidic protein (GFAP), consistent with activation of astrocytes (M.L. Nordlund, T.A. Rizvi, C.I. Brannan, N. Ratner, Neurofibromin expression and astrogliosis in neurofibromatosis (type 1) brains, J. Neuropathol. Exp. Neurology 54 (1995) 588-600). We analyzed brains from transgenic mice in which the Nf1 gene was targeted by homologous recombination. We show here that, in all heterozygous mice analyzed there are increased numbers of astrocytes expressing high levels of GFAP in medial regionsof the periaqueductal gray and in the nucleus accumbens. More subtle, but significant, changes in the number of GFAP positive astrocytes were observed in the hippocampus in 60% of mutant mice analyzed. Astrocytes with elevated GFAP were present at 1 month, 2 months, 6 months and 12 months after birth. Most brain regions, including the cerebellum, basal ganglia, cerebral cortex, hypothalamus, thalamus, cortical amygdaloid area, and white matter tracts did not show any gliotic changes. No evidence of degenerating neuronswas found using de Olmos' cupric silver stain. We conclude that Nf1/nf1 mice provide a model to study astrogliosis associated with neurofibromatosis type 1. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 10/04/20 alle ore 00:19:40