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Titolo:
A study of novel antiallergic agents with eosinophilic infiltration inhibiting action
Autore:
Kawasaki, N; Miyataka, H; Matsumoto, H; Yamashita, N; Sakane, T; Mizushima, Y; Satoh, T;
Indirizzi:
Tokushima Bunri Univ, Fac Pharmaceut Sci, Tokushima 7708514, Japan Tokushima Bunri Univ Tokushima Japan 7708514 i, Tokushima 7708514, Japan St Marianna Univ, Sch Med, Inst Med Sci, Kawasaki, Kanagawa 2168511, JapanSt Marianna Univ Kawasaki Kanagawa Japan 2168511 Kanagawa 2168511, Japan
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 1, volume: 9, anno: 1999,
pagine: 19 - 24
SICI:
0960-894X(19990104)9:1<19:ASONAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ASTHMA; LEUKOTRIENE-B4; MEDIATORS; POTENT; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Satoh, T Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro Cho, Tokushima 7708514, Tokushima Bunri Univ Yamashiro Cho Tokushima Japan 7708514 8514,
Citazione:
N. Kawasaki et al., "A study of novel antiallergic agents with eosinophilic infiltration inhibiting action", BIOORG MED, 9(1), 1999, pp. 19-24

Abstract

The antiallergic action of a series of novel mono-O-substituted trimethylhydroquinones was investigated. Among this series of the compounds, 4-[4-[4-(diphenylmethyl)-1-piperazinyl]butoxy]-2,3,6-trimethylphenol (compound 3) showed a potent antihistaminic action (pA(2)=7.11) and an antiasthmatic action (100 mg/kg p. o.) on sensitized guinea pigs. Moreover, this compound exhibited a strong eosinophilic infiltration inhibiting action on sensitized mice (100 mg/kg p. o.). (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 09:07:25