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Titolo:
P300 subcomponents reflect different aspects of psychopathology in schizophrenia
Autore:
Frodl-Bauch, T; Gallinat, J; Meisenzahl, EM; Moller, HJ; Hegerl, U;
Indirizzi:
Univrmanych, Hosp Psychiat, Dept Clin Neurophysiol, EEG, D-80336 Munich, Ge Univ Munich Munich Germany D-80336 Neurophysiol, EEG, D-80336 Munich, Ge
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 1, volume: 45, anno: 1999,
pagine: 116 - 126
SICI:
0006-3223(19990101)45:1<116:PSRDAO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; NEGATIVE SYMPTOMS; AUDITORY P300; INTRACEREBRAL POTENTIALS; CHOLINERGIC MODULATION; CLINICAL-FEATURES; VISUAL-STIMULI; LONG-LATENCY; RARE TARGET; TOPOGRAPHY;
Keywords:
evoked potential; P3a; P3b; hemispheric differences; positive and negative symptoms; neurotransmitter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Frodl-Bauch, T Univ0336ich, Hosp Psychiat, Dept Clin Neurophysiol, EEG, Nussbaumstr 7, D-8 Univ Munich Nussbaumstr 7 Munich Germany D-80336 tr 7, D-8
Citazione:
T. Frodl-Bauch et al., "P300 subcomponents reflect different aspects of psychopathology in schizophrenia", BIOL PSYCHI, 45(1), 1999, pp. 116-126

Abstract

Background: The aim of the study was to investigate abnormalities of P300 subcomponents in schizophrenic patients as well as relationships between these subcomponents and positive versus negative schizophrenic symptoms. Methods: Nineteen schizophrenic patients and 19 healthy controls were tested with an auditory event-related potential oddball paradigm designed to elicit the P300. The P300 data were analyzed by separating P300 subcomponentswith a recently developed dipole source model. Results: Compared to healthy controls, schizophrenic patients showed reduced P300 amplitudes of the temporo-basal dipoles, corresponding mainly to P3b. Positive symptoms of the Positive and Negative Syndrome Scale correlatedpositively with the temporo-basal but not with temporo-superior dipole P300 activities, whereas negative symptoms correlated positively with the temporo-superior but nor with temporo-bar;al dipole activities. Conclusions: The P300 subcomponents separated with the dipole model are affected in a different manner by positive versus negative symptoms. Furthermore, the positive correlation between the severity of psychopathology and the P300 amplitudes of the different dipole activities appears to be a state-dependent effect, which has to be separated from the P300 amplitude reduction as a trait marker in schizophrenic patients. Biol Psychiatry 1999; 45:116-126 (C) 1999 Society of Biological Psychiatry.

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Documento generato il 31/03/20 alle ore 17:57:28