Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Neuroendocrine response to antipsychotics: Effects of drug type and gender
Autore:
Grunder, G; Wetzel, H; Schlosser, R; Anghelescu, I; Hillert, A; Lange, K; Hiemke, C; Benkert, O;
Indirizzi:
Univ Mainz, Dept Psychiat, D-55131 Mainz, Germany Univ Mainz Mainz Germany D-55131 , Dept Psychiat, D-55131 Mainz, Germany
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 1, volume: 45, anno: 1999,
pagine: 89 - 97
SICI:
0006-3223(19990101)45:1<89:NRTAEO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROTROPIN-RELEASING-HORMONE; SCHIZOPHRENIC-PATIENTS; GROWTH-HORMONE; PROLACTIN SECRETION; CLINICAL-RESPONSE; SERUM PROLACTIN; HUMAN PITUITARY; RECEPTOR ANTAGONIST; LIMBIC SELECTIVITY; PLASMA-LEVELS;
Keywords:
amisulpride; flupenthixol; prolactin; thyrotropin; growth hormone; thyrotropin-releasing hormone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Grunder, G Univ Mainz, Dept Psychiat, Untere Zahlbacher Str 8, D-55131 Mainz, Germany Univ Mainz Untere Zahlbacher Str 8 Mainz Germany D-55131 rmany
Citazione:
G. Grunder et al., "Neuroendocrine response to antipsychotics: Effects of drug type and gender", BIOL PSYCHI, 45(1), 1999, pp. 89-97

Abstract

Background: To study the influences of drug type and gender on the neuroendocrine response to neuroleptic treatment we compared the endocrine actionsof two neuroleptics with different receptor affinity profiles-a substituted benzamide, amisulpride, a selective D-2-like dopamine antagonist; and a thioxanthene, flupenthixol, a mixed D-1/D-2-like antagonist also blocking serotonin, H-1, and D-1 receptors-on anterior pituitary hormone secretion in schizophrenic patients (DSM-III-R). Methods: Blood was withdrawn at 15-min intervals to assess basal secretionof prolactin, growth hormone (GH), and thyroid-stimulating hormone (TSH). Four hundred micrograms of thyrotropin-releasing hormone (TRH) was injectedIV to investigate drug effects on TRH-stimulated secretion of prolactin TSH, and GH. Results: Prolactin plasma levels were markedly elevated in both treatment groups. In female, but not in male patients, this elevation was significantly more pronounced under amisulpride than under flupenthixol, The prolactinresponse to TRH was significantly blunted by amisulpride only in male subjects. While basal TSH secretion was significantly increased by both compounds, TRH-stimulated TSH secretion was elevated only in patients treated withamisulpride. Low basal prolactin levels predicted improvement of negative symptoms in patients treated with amisulpride. Conclusions: Amisulpride's more pronounced endocrine effects may be a reflection of its distinguished pharmacology and pharmacokinetics. Biol Psychiatry 1999;45: 89-97 (C) 1999 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 07:21:15