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Titolo:
DOPAMINE D-1 AND D-2 RECEPTOR-BINDING SITES IN BRAIN SAMPLES FROM DEPRESSED SUICIDES AND CONTROLS
Autore:
BOWDEN C; THEODOROU AE; CHEETHAM SC; LOWTHER S; KATONA CLE; CROMPTON MR; HORTON RW;
Indirizzi:
ST GEORGE HOSP,SCH MED,DEPT PHARMACOL & CLIN PHARMACOL LONDON SW17 0RE ENGLAND ST GEORGE HOSP,SCH MED,DEPT PHARMACOL & CLIN PHARMACOL LONDON SW17 0RE ENGLAND NE SURREY COLL TECHNOL,FAC SCI & TECHNOL EPSOM KT17 3DS SURREY ENGLAND KNOLL PHARMACEUT RES & DEV NOTTINGHAM NG1 1GF ENGLAND UNIV COLL LONDON,SCH MED,DEPT PSYCHIAT LONDON W1N 8AA ENGLAND ST GEORGE HOSP,SCH MED,DEPT FORENS MED LONDON SW17 0RE ENGLAND
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 752, anno: 1997,
pagine: 227 - 233
SICI:
0006-8993(1997)752:1-2<227:DDADRS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; RAT STRIATUM; AMINE METABOLITES; LIMBIC SYSTEM; AFFECTIVE-DISORDERS; HOMOVANILLIC-ACID; AFFECTIVE-ILLNESS; GROWTH-HORMONE; H-3 SCH-23390; DOUBLE-BLIND;
Keywords:
DOPAMINE D-1 RECEPTOR BINDING SITE; DOPAMINE D-2 RECEPTOR BINDING SITE; DEPRESSION; SUICIDE; POSTMORTEM BRAIN TISSUE; ANTIDEPRESSANT DRUG; NEUROLEPTIC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
C. Bowden et al., "DOPAMINE D-1 AND D-2 RECEPTOR-BINDING SITES IN BRAIN SAMPLES FROM DEPRESSED SUICIDES AND CONTROLS", Brain research, 752(1-2), 1997, pp. 227-233

Abstract

Dopamine D-1 and D-2 receptors were measured (by saturation binding of [H-3]SCH23390 and [H-3]raclopride) in caudate; putamen and nucleus accumbens, obtained at post-mortem from suicide victims with a firm retrospective diagnosis of depression, and matched controls. There were no differences in the number or affinity of D-1 or D-2 receptors between suicides who had been free of antidepressants for at least three months prior to death, and controls. Increased numbers and decreased affinity of D-2 receptors were however found in each brain region of antidepressant-treated suicides. We argue that these increases are related to concurrent treatment with neuroleptics rather than a direct effect of antidepressants. Increased numbers of D-1 receptors in antidepressant-treated suicides were seen only in nucleus accumbens. This increasecould not be clearly attributed to neuroleptics and may be related toantidepressant treatment. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 17:21:40