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Titolo:
PHYSIOLOGICAL EVIDENCE FOR HIPPOCAMPAL DISINHIBITION RESULTING FROM ACTIVATION OF THE MEDIAN RAPHE
Autore:
KAO K; SANDERS MJ; GREEN EJ;
Indirizzi:
UNIV MIAMI,DEPT PSYCHOL,POB 248185 CORAL GABLES FL 33124 UNIV MIAMI,DEPT PSYCHOL CORAL GABLES FL 33124
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 752, anno: 1997,
pagine: 90 - 98
SICI:
0006-8993(1997)752:1-2<90:PEFHDR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT DENTATE GYRUS; NEURONAL TRANSMISSION; INHIBITORY INTERNEURONS; PERFORANT PATHWAY; FIELD POTENTIALS; MIDBRAIN RAPHE; GRANULE CELLS; UNIT-ACTIVITY; SEROTONIN; PROJECTIONS;
Keywords:
DENTATE GYRUS; INTERNEURON; SINGLE UNIT; POPULATION SPIKE; FIELD POTENTIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
K. Kao et al., "PHYSIOLOGICAL EVIDENCE FOR HIPPOCAMPAL DISINHIBITION RESULTING FROM ACTIVATION OF THE MEDIAN RAPHE", Brain research, 752(1-2), 1997, pp. 90-98

Abstract

The mechanism underlying median raphe (MR)-induced facilitation of hippocampal synaptic transmission was investigated by recording stimulus-evoked field potentials and unitary responses in urethane-anesthetized rats. Stimulation of the MR 40 ms prior to perforant path (PP) activation significantly increased the magnitude of PP-evoked granule cell population spikes (median increase = 78%) without affecting populationEPSP slope. Injection of homocysteic acid into the vicinity of the MRalso facilitated PP-evoked granule cell population spikes, in a dose-dependent manner. Nineteen dentate hilar units were characterized as putative interneurons on the basis of their waveform characteristics and their response to PP stimulation. Electrical activation of the MR inhibited spontaneous or PP-evoked activity in the majority (75%) of these cells; the remaining cells were unaffected. MR stimulation also inhibited spontaneous activity in a large proportion (60%) of putative interneurons in CA1. The present results provide evidence that neurons within the raphe modulate hippocampal throughput by altering discharge of non-principal cells. These data, thus, support the idea that disinhibition is a common mechanism by which extrahippocampal structures modulate information now through the hippocampus. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:52:43