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Titolo:
Sevoflurane selectively increases coronary collateral blood flow independent of K-ATP channels in vivo
Autore:
Kersten, JR; Schmeling, T; Tessmer, J; Hettrick, DA; Pagel, PS; Warltier, DC;
Indirizzi:
MedWIoll Wisconsin, Zablocki Vet Adm Med Ctr, Dept Anesthesiol, Milwaukee,Med Coll Wisconsin Milwaukee WI USA 53226 r, Dept Anesthesiol, Milwaukee, Medwaukee,isconsin, Zablocki Vet Adm Med Ctr, Dept Pharmacol & Toxicol, Mil Med Coll Wisconsin Milwaukee WI USA 53226 , Dept Pharmacol & Toxicol, Mil Med Coll Wisconsin, Zablocki Vet Adm Med Ctr, Dept Med, Div Cardiovasc Dis, Med Coll Wisconsin Milwaukee WI USA 53226 , Dept Med, Div Cardiovasc Dis, Marquette Univ, Dept Biomed Engn, Milwaukee, WI 53233 USA Marquette Univ Milwaukee WI USA 53233 iomed Engn, Milwaukee, WI 53233 USA
Titolo Testata:
ANESTHESIOLOGY
fascicolo: 1, volume: 90, anno: 1999,
pagine: 246 - 256
SICI:
0003-3022(199901)90:1<246:SSICCB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSITIVE POTASSIUM CHANNELS; INSTRUMENTED CANINE MODEL; ARTERY OCCLUSION; ISOFLURANE; HALOTHANE; DOGS; VASODILATION; ADENOSINE; NICORANDIL; ENFLURANE;
Keywords:
coronary collateral circulation; myocardial ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kersten, JR Med2C,8701isconsin, Zablocki Vet Adm Med Ctr, Dept Anesthesiol, MEB,Room 46 Med Coll Wisconsin MEB,Room 462C,8701 Watertown Plank Rd Milwaukee WI USA 53226
Citazione:
J.R. Kersten et al., "Sevoflurane selectively increases coronary collateral blood flow independent of K-ATP channels in vivo", ANESTHESIOL, 90(1), 1999, pp. 246-256

Abstract

Background: Volatile anesthetic agents produce coronary vasodilation via activation of adenosine triphosphate-sensitive potassium (K-ATP) channels. The authors tested the hypothesis that sevoflurane selectively increases coronary collateral blood flow and assessed the role of K-ATP channel activation in this process. Methods: Experiments were conducted in dogs 8 weeks after long-term implantation of a left anterior descending coronary artery (LAD) ameroid constrictor to stimulate coronary collateral growth, Dogs were instrumented for measurement of retrograde LAD blood flow tan index of large coronary collateral blood flow) and LAD tissue flow (via radioactive microspheres; an index of small collateral blood flow). Coronary collateral perfusion and normal (left circumflex coronary artery [LCCA]) zone tissue blood flow were determined in four groups of dogs pretreated with intracoronary glyburide (50 mu g/kg) or vehicle in the presence or absence of sevoflurane (1 minimum alveolar concentration). Dose-response relationships to the K-ATP channel agonist nicorandil were established in each dog using doses (25, 50, and 100 mu g/min) previously shown to increase coronary collateral blood flow. Results: Sevoflurane increased blood flow through large and small collaterals and increased collateral vascular conductance in the presence of glyburide but did not affect LCCA blood flow or conductance, In contrast, nicorandil increased blood flow through small but not large collaterals. Nicorandil also increased LCCA blood flow and conductance, actions that were attenuated by glyburide,Conclusions: The results demonstrate that sevoflurane selectively increases large and small coronary collateral blood flow via mechanism(s) independent of K-ATP channel activation.

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Documento generato il 04/04/20 alle ore 12:06:35