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Titolo:
MR-IMAGING OF DOUBLE-CONTRAST ENHANCED PORCINE MYOCARDIAL-INFARCTION - CORRELATION WITH MICRODIALYSIS
Autore:
NILSSON S; WIKSTROM M; ERICSSON A; WIKSTROM G; WALDENSTROM A; OKSENDAL A; HEMMINGSSON A;
Indirizzi:
AKAD SJUKHUSET S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT DIAGNOST RADIOL S-75185 UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT INTERNAL MED S-75185 UPPSALA SWEDEN NYCOMED IMAGING AS OSLO NORWAY
Titolo Testata:
Acta radiologica
fascicolo: 4, volume: 36, anno: 1995,
pagine: 346 - 352
SICI:
0284-1851(1995)36:4<346:MODEPM>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA;
Keywords:
HEART, INFARCTION; MR, CONTRAST MEDIA; GD-DTPA-BMA; DSI-DTPA-BMA; EXPERIMENTAL; MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
S. Nilsson et al., "MR-IMAGING OF DOUBLE-CONTRAST ENHANCED PORCINE MYOCARDIAL-INFARCTION - CORRELATION WITH MICRODIALYSIS", Acta radiologica, 36(4), 1995, pp. 346-352

Abstract

MR imaging was performed to investigate whether Gd-DTPA-BMA-induced contrast enhancement of myocardial infarction is counteracted by Dy-DTPA-BMA. Myocardial infarction was induced in 5 pigs. Microdialysate probes were inserted in ischemic and nonischemic myocardium. Gd-DTPA-BMA (0.3 mmol/kg b.w.) and Dy-DTPA-BMA (1.0 mmol/kg b.w.) were administered i.v. 4 hours post occlusion. The microdialysate was collected every 10 min and measured for Gd and Dy using inductively coupled plasma atomic emission spectrometry. The pigs were sacrificed 2 hours after administration of contrast media. The concentration of both contrast agents was 3 times higher in infarcted myocardium than in nonischemic myocardium. The infarctions displayed high signal intensity in spin-echo sequences ex vivo. This lack of detectable susceptibility effects from Dy may be caused by loss of cell membrane integrity in infarcted tissueas shown by our microdialysate and biopsy data.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:35:43