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Titolo:
Malaria diagnosis by dipstick assay in a Honduran population with coendemic Plasmodium falciparum and Plasmodium vivax
Autore:
Quintana, M; Piper, R; Boling, HL; Makler, M; Sherman, C; Gill, E; Fernandez, E; Martin, S;
Indirizzi:
Walteruneed Army Med Ctr, Walter Reed Army Inst Res, Dept Entomol, Div Comm Walter Reed Army Med Ctr Washington DC USA 20307 , Dept Entomol, Div Comm Flow Inc, Portland, OR 97201 USA Flow Inc Portland OR USA 97201Flow Inc, Portland, OR 97201 USA Joint Task Force Bravo Soto Cono Air Base, Soto Cono, Honduras Joint Task Force Bravo Soto Cono Air Base Soto Cono Honduras , Honduras Minist Hlth, Div Vector Borne Dis, Tegucigalpa, Honduras Minist Hlth Tegucigalpa Honduras ector Borne Dis, Tegucigalpa, Honduras
Titolo Testata:
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
fascicolo: 6, volume: 59, anno: 1998,
pagine: 868 - 871
SICI:
0002-9637(199812)59:6<868:MDBDAI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; ANTIGEN-CAPTURE ASSAY; LACTATE-DEHYDROGENASE; IDENTIFICATION; SENSITIVITY; INFECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Quintana, M Walteruneed Army Med Ctr, Walter Reed Army Inst Res, Dept Entomol, Div Comm Walter Reed Army Med Ctr Washington DC USA 20307 ol, Div Comm
Citazione:
M. Quintana et al., "Malaria diagnosis by dipstick assay in a Honduran population with coendemic Plasmodium falciparum and Plasmodium vivax", AM J TROP M, 59(6), 1998, pp. 868-871

Abstract

A Plasmodium lactate dehydrogenase dipstick designed to separately detect P. falciparum and P. vivax malaria was evaluated in two Honduran populations where both species are endemic. The dipstick: was compared to thick him microscopy; the polymerase chain reaction (PCR) was used to analyze discordant results. The dipstick had a sensitivity of 100% and a specificity of 95%compared with microscopy in the diagnosis of Plasmodium infections in a hospital population; the mean parasite density was approximately 590/mm(3). In a field sample of mostly asymptomatic volunteers, the sensitivity of the dipstick for Plasmodium infection varied with parasite density. Additionally, the sensitivity and specificity of the dipstick was similar to thick film microscopy in the diagnosis of vivax malaria compared with the PCR. The dipstick was unable to detect P. vivax in the presence of P. falciparum because of cross-reactivity in the pan-specific band. Accurate species identification in mixed infections remains a problem in malaria diagnosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:27:14