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Titolo:
Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: Implications in addiction
Autore:
Volkow, ND; Wang, GJ; Fowler, JS; Hitzemann, R; Angrist, B; Gatley, SJ; Logan, J; Ding, YS; Pappas, N;
Indirizzi:
Brookhaven Natl Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 Lab, Dept Med, Upton, NY 11973 USA Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 ab, Dept Chem, Upton, NY 11973 USA SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 hiat, Stony Brook, NY 11794 USA NYU, Dept Psychiat, New York, NY 10016 USA NYU New York NY USA 10016NYU, Dept Psychiat, New York, NY 10016 USA
Titolo Testata:
AMERICAN JOURNAL OF PSYCHIATRY
fascicolo: 1, volume: 156, anno: 1999,
pagine: 19 - 26
SICI:
0002-953X(199901)156:1<19:AOMCWC>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN GLUCOSE-METABOLISM; CEREBRAL BLOOD-FLOW; MARIJUANA INTOXICATION; NEURONAL-ACTIVITY; DOPAMINE; PET; BINDING; MONKEY; CORTEX; PROJECTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Volkow, ND Brookhaven Natl Lab, Dept Med, Bldg 490, Upton, NY 11973 USA Brookhaven Natl Lab Bldg 490 Upton NY USA 11973 n, NY 11973 USA
Citazione:
N.D. Volkow et al., "Association of methylphenidate-induced craving with changes in right striato-orbitofrontal metabolism in cocaine abusers: Implications in addiction", AM J PSYCHI, 156(1), 1999, pp. 19-26

Abstract

Objective: The authors have shown that decreases in dopamine D-2 receptorsin cocaine abusers were associated with decreased metabolism in the cingulate and prefrontal and orbitofrontal cortices. To assess whether increasingdopamine would reverse these metabolic decrements, they measured the effects of methylphenidate, a drug that increases dopamine, on brain glucose metabolism in 20 cocaine abusers. Method: The subjects underwent two [F-18]fluorodeoxyglucose positron emission tomography scans, one after two sequential placebo injections and one after two intravenous doses of methylphenidate. D2 receptors were measured with [C-11]raclopride to evaluate their relation to methylphenidate-induced metabolic changes. Results: Methylphenidate induced variable changes in brain metabolism: subjects with the higher D2 measures tended to increase metabolism, whereas those with the lower D2 measures tended to decrease metabolism. Methylphenidate's effects were significant for increases in metabolism in the superior cingulate, right thalamus, and cerebellum. Methylphenidate-induced changes in the right orbitofrontal cortex and right striatum were associated with craving, and those in the prefrontal cortex were associated with mood. Conclusions: Although methylphenidate increased metabolism in the superior cingulate, it only increased metabolism in orbitofrontal or prefrontal cortices in the subjects in whom it enhanced craving and mood, respectively. This indicates that dopamine enhancement is not sufficient per se to increase metabolism in these frontal regions. Activation of the right orbitofrontal cortex and right striatum (brainregions found to be abnormal in compulsive disorders) in the subjects reporting craving may be one of the mechanisms underlying compulsive drug administration in addicted persons. The predominant correlation of craving with right but not left brain regions suggests laterality of reinforcing and/or conditioned responses.

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Documento generato il 19/01/20 alle ore 20:24:37