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Titolo:
Hypoxic regions exist in human prostate carcinoma
Autore:
Movsas, B; Chapman, JD; Horwitz, EM; Pinover, WH; Greenberg, RE; Hanlon, AL; Iyer, R; Hanks, GE;
Indirizzi:
Fox Chase Canc Ctr, Dept Radiat Oncol, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA Fox Chase Canc Ctr, Dept Surg Oncol, Philadelphia, PA 19111 USA Fox Chase Canc Ctr Philadelphia PA USA 19111 , Philadelphia, PA 19111 USA
Titolo Testata:
UROLOGY
fascicolo: 1, volume: 53, anno: 1999,
pagine: 11 - 18
SICI:
0090-4295(199901)53:1<11:HREIHP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; TUMOR HYPOXIA; OXYGEN DISTRIBUTION; RADIATION-THERAPY; ADVANCED CANCER; UTERINE CERVIX; RADIOTHERAPY; TRIAL; HEAD; NECK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Movsas, B Foxa,hase Canc Ctr, Dept Radiat Oncol, 7701 Burholme Ave,C-112, Philadelphi Fox Chase Canc Ctr 7701 Burholme Ave,C-112 Philadelphia PA USA 19111
Citazione:
B. Movsas et al., "Hypoxic regions exist in human prostate carcinoma", UROLOGY, 53(1), 1999, pp. 11-18

Abstract

Objectives. The purpose of this study was to characterize, by use of the Eppendorf microelectrode, the extent of hypoxia (range/heterogeneity) in human prostate carcinomas,Methods. Custom-made Eppendorf pO(2) microelectrodes were used to obtain pO(2) measurements from the pathologically involved side of the prostate, aswell as from a region of normal muscle for comparison. Each set of measurements comprised approximately 100 separate readings of pO(2), for a total of 2145 individual measurements. Twelve patients were studied, 7 of whom underwent brachytherapy, 3 a radical prostatectomy, and 2 a cystoprostatectomy. The pO(2) measurements were obtained in the operating room, using steriletechnique, under spinal anesthesia for the brachytherapy group patients and under general anesthesia for the surgery group patients. The Eppendorf histograms were recorded and described by the median pO(2), mean pO(2), and percentage of measurements less than 5 mm Hg and less than 10 mm Hg. Results, Because of differences in patient characteristics and the anesthesia employed, control measurements were obtained from nearby normal muscle as an internal control in all but 2 patients. This internal comparison showed that the oxygen measurements from the pathologically involved portion ofthe prostate were significantly lower than those from normal muscle. Similarly, higher pO(2) readings were obtained from the pathologically normal prostates (in the patients with bladder cancer) than from the prostates of patients with prostate carcinoma. Increasing levels of hypoxia were observed with increasing clinical stage. Significant predictors of oxygenation include the type of tissue (pathologically involved prostate versus normal muscle or normal prostate), clinical stage, and type of anesthesia. Conclusions. This report, to our knowledge, represents the first study to obtain in vivo electrode measurements of oxygen levels in patients with prostate cancer and suggests that hypoxic regions exist in human prostate carcinoma. More patients will be accrued to this prospective study to correlatethe oxygenation status of prostate carcinoma with known prognostic factorsand treatment outcome. UROLOGY 53: 11-18, 1999. (C) 1999, Elsevier ScienceInc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 00:49:44