Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evaluation of the developmental toxicity of methacrylamide and N,N '-methylenebisacrylamide in Swiss mice
Autore:
George, JD; Price, CJ; Marr, MC; Myers, CB; Schwetz, BA; Heindel, JJ;
Indirizzi:
Res Triangle Inst, Res Triangle Pk, NC 27709 USA Res Triangle Inst Res Triangle Pk NC USA 27709 Triangle Pk, NC 27709 USA NIEHS,27709 Toxicol Program, Dev & Reprod Toxicol Grp, Res Triangle Pk, NCNIEHS Res Triangle Pk NC USA 27709 eprod Toxicol Grp, Res Triangle Pk, NC
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 1, volume: 46, anno: 1998,
pagine: 124 - 133
SICI:
1096-6080(199811)46:1<124:EOTDTO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZERO DOSE CONTROL; GAMMA-SCINTIGRAPHY; DNA FRAGMENTS; ELECTROPHORESIS; DOXORUBICIN; POLYMER; RAT; GALACTOSAMINE; COPOLYMERS; ACRYLAMIDE;
Keywords:
acrylamides; developmental toxicity; teratogenicity; mice; morphological development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: George, JD Res Triangle Inst, POB 12194, Res Triangle Pk, NC 27709 USA ResTriangle Inst POB 12194 Res Triangle Pk NC USA 27709 09 USA
Citazione:
J.D. George et al., "Evaluation of the developmental toxicity of methacrylamide and N,N '-methylenebisacrylamide in Swiss mice", TOXICOL SCI, 46(1), 1998, pp. 124-133

Abstract

Timed-pregnant CD-1 outbred albino Swiss mice received either methacrylamide (MAC; 0, 60, 120, or 180 mg/kg/day) or N,N'-methylenebisacrylamide (BAC;0, 3, 10, or 30 mg/kg/day) po in distilled water on gestational days (GD) 6 through 17. Maternal clinical status was monitored daily. At termination (GD 17), confirmed-pregnant females (27-30 per group, MAC; 24-25 per group,BAG) were evaluated for clinical status and gestational outcome; live fetuses were examined for external, visceral, and skeletal malformations. For MAC, no treatment-related maternal mortality was observed. Maternal body weight on GD 17, maternal weight gain during treatment and gestation, and corrected maternal weight gain were reduced at the high dose. Relative maternalfood and water intake was not adversely affected; neurotoxicity was not observed. Relative maternal liver weight was increased at greater than or equal to 120 mg/kg/day; gravid uterine weight was decreased at 180 mg/kg/day. The maternal no-observed adverse effect level (NOAEL) was 60 mg/kg/day. TheNOAEL for developmental toxicity was also 60 mg/kg/day. At greater than orequal to 120 mg/kg/day, mean fetal body weight was reduced. At 180 mg/kg/day, increased postimplantation death per litter was observed. Morphologicaldevelopment was not affected. The maternal NOAEL for BAC was 10 mg/kg/day. At 30 mg/kg/day, decreased maternal body weight on GD 17, maternal body weight change during treatment and gestation, corrected maternal body weight,and gravid uterine weight were observed. Relative maternal liver weight increased at 30 mg/kg/day. The developmental NOAEL was 3 mg/kg/day BAG. Mean fetal body weight was reduced at 30 mg/kg/day. At greater than or equal to 10 mg/kg/day, an increased incidence of fetal variations (extra rib) was observed, although fetal malformation rate was unaffected. MAC and BAC were not teratogenic to Swiss mice at the doses tested. BAC was more potent than MAC in causing adverse maternal and developmental effects. (C) 1998 Societyof Toxicology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:31:29