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Titolo:
A decrease of reelin expression as a putative vulnerability factor in schizophrenia
Autore:
Impagnatiello, F; Guidotti, AR; Pesold, C; Dwivedi, Y; Caruncho, H; Pisu, MG; Uzunov, DP; Smalheiser, NR; Davis, JM; Pandey, GN; Pappas, GD; Tueting, P; Sharma, RP; Costa, E;
Indirizzi:
UnivAIllinois, Dept Psychiat, Coll Med, Inst Psychiat, Chicago, IL 60612 US Univ Illinois Chicago IL USA 60612 d, Inst Psychiat, Chicago, IL 60612 US Univompostela de Compostela, Sch Biol, Dept Fundamental Biol, Santiago De C Univ Santiago de Compostela Santiago De Compostela Spain 15706 iago De C
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 26, volume: 95, anno: 1998,
pagine: 15718 - 15723
SICI:
0027-8424(199812)95:26<15718:ADOREA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICAL DEVELOPMENT; GENE; DYSFUNCTION; TOLERANCE; CORTEX; BRAIN; LOBE; ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Impagnatiello, F Univicago,ois, Dept Psychiat, Coll Med, Inst Psychiat, 1601 W Taylor St, Ch Univ Illinois 1601 W Taylor St Chicago IL USA 60612 t, Ch
Citazione:
F. Impagnatiello et al., "A decrease of reelin expression as a putative vulnerability factor in schizophrenia", P NAS US, 95(26), 1998, pp. 15718-15723

Abstract

Postmortem prefrontal cortices (PFC) (Brodmann's areas 10 and 46), temporal cortices (Brodmann's area 22), hippocampi, caudate nuclei, and cerebella of schizophrenia patients and their matched nonpsychiatric subjects were compared for reelin (RELN) mRNA and reelin (RELN) protein content. In all of the brain areas studied, RELN and its mRNA were significantly reduced ( approximate to 50%) in patients with schizophrenia; this decrease was similar in patients affected by undifferentiated or paranoid schizophrenia. To exclude possible artifacts caused by postmortem mRNA degradation, we measured the mRNAs in the same PFC extracts from gamma-aminobutyric acid (GABA)(A) receptors alpha(1) and alpha(5) and nicotinic acetylcholine receptor alpha(7)subunits. Whereas the expression of the alpha(7) nicotinic acetylcholine receptor subunit was normal, that of the alpha(1) and alpha(5) receptor subunits of GABA(A) was increased when schizophrenia was present. RELN mRNA waspreferentially expressed in GABAergic interneurons of PFC, temporal cortex, hippocampus, and glutamatergic granule cells of cerebellum. A protein putatively functioning as an intracellular target for the signal-transduction cascade triggered by RELN protein released into the extracellular matrix istermed mouse disabled-1 (DAB1) and is expressed at comparable levels in the neuroplasm of the PFC and hippocampal pyramidal neurons, cerebellar Purkinje neurons of schizophrenia patients, and nonpsychiatric subjects; these three types of neurons do not express RELN protein. In the same samples of temporal cortex, we found a decrease in RELN protein of approximate to 50% but no changes in DAB1 protein expression. We also observed a large (up to 70%) decrease of GAD67 but only a small decrease of GAD65 protein content. These findings are interpreted within a neurodevelopmental/vulnerability "two-hit" model for the etiology of schizophrenia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 02:21:05