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Titolo:
Basic fibroblast growth factor in experimental and clinical bacterial meningitis
Autore:
Huang, CC; Liu, CC; Wang, ST; Chang, YC; Yang, HB; Yeh, TF;
Indirizzi:
Natl Cheng Kung Univ, Med Ctr, Dept Pediat, Tainan 704, Taiwan Natl Cheng Kung Univ Tainan Taiwan 704 , Dept Pediat, Tainan 704, Taiwan Natl Cheng Kung Univ, Med Ctr, Dept Publ Hlth, Tainan 70101, Taiwan Natl Cheng Kung Univ Tainan Taiwan 70101 Publ Hlth, Tainan 70101, Taiwan Kaohsiung Chang Gung Children Hosp, Dept Pediat, Kaohsiung, Taiwan Kaohsiung Chang Gung Children Hosp Kaohsiung Taiwan , Kaohsiung, Taiwan Natl Cheng Kung Univ, Med Ctr, Dept Pathol, Tainan 70101, Taiwan Natl Cheng Kung Univ Tainan Taiwan 70101 pt Pathol, Tainan 70101, Taiwan
Titolo Testata:
PEDIATRIC RESEARCH
fascicolo: 1, volume: 45, anno: 1999,
pagine: 120 - 127
SICI:
0031-3998(199901)45:1<120:BFGFIE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; PNEUMOCOCCAL MENINGITIS; CEREBROSPINAL-FLUID; FACTOR EXPRESSION; BINDING-PROTEIN; MESSENGER-RNA; AMINO-ACIDS; RAT-BRAIN; IN-VIVO; ANGIOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, CC Natliwanng Kung Univ, Med Ctr, Dept Pediat, 138 Sheng Li Rd, Tainan 704, Ta Natl Cheng Kung Univ 138 Sheng Li Rd Tainan Taiwan 704 704, Ta
Citazione:
C.C. Huang et al., "Basic fibroblast growth factor in experimental and clinical bacterial meningitis", PEDIAT RES, 45(1), 1999, pp. 120-127

Abstract

Basic fibroblast growth factor (bFGF), a neurotrophic factor in the CNS, is expressed at high levels in response to seizures or strokes. We examined the expression of bFGF during experimental bacterial meningitis and the levels of bFGF in the cerebrospinal fluid (CSF) of children with bacterial meningitis. For the experimental study, a mouse model of meningitis was established by intracranial injection of Streptococcus pneumoniae. Twenty-four hours after induced meningitis, the brains were sectioned and stained immunohistochemically for bFGF. Neutrophils and macrophages infiltrating the leptomeninges and the ventricles exhibited strong bFGF immunoreactivity. The neurons in the areas adjacent to the inflamed ventricles also showed enhanced bFGF expression. For the clinical study, we used an enzyme immunoassay to measure bFGF in CSF in 18 children with bacterial meningitis, 12 with aseptic meningitis, and 18 controls. The CSF levels of bFGF were twice as high inchildren with bacterial meningitis (medians 6.75-7.21 pg/mL) compared withthose who had aseptic meningitis (2.9 pg/mL) or in control subjects (2.65 pg/mL, p < 0.0001, respectively), In patients with bacterial meningitis whosurvived, CSF bFGF decreased significantly after 24-50 h of antibiotic therapy (p < 0.0005). Patients who developed major sequelae or died had much higher levels of CSF bFGF than those without (134.9 pg/mL versus 7.38 pg/mL,p < 0.05). These findings of enhanced immunoreactivity of bFGF in experimental bacterial meningitis and an association of CSF levels of bFGF with disease severity in childhood bacterial meningitis suggest a biologic role forthis neurotrophic factor in the pathophysiology of bacterial meningitis.

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Documento generato il 15/07/20 alle ore 12:29:06