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Titolo:
Synthesis and degradation of collagen in pancreatic fibrogenesis
Autore:
Valderrama, R; Navarro, S; Lopez, JM; Caballeria, J; Gimenez, A; Pares, A; Adrian, MJ; Fernandez-Cruz, L; Teres, J;
Indirizzi:
Univurg,celona, Hosp Clin Barcelona, Dept Med, Inst Malalties Digest,Dept S Univ Barcelona Barcelona Spain E-08036 Med, Inst Malalties Digest,Dept S UnivBarcelona,, Hosp Clin Barcelona, Dept Med, Serv Gastroenterol, E-08036Univ Barcelona Barcelona Spain E-08036 Med, Serv Gastroenterol, E-08036 Univa,arcelona, Hosp Clin Barcelona, Dept Med, Liver Unit, E-08036 Barcelon Univ Barcelona Barcelona Spain E-08036 Med, Liver Unit, E-08036 Barcelon
Titolo Testata:
PANCREAS
fascicolo: 1, volume: 18, anno: 1999,
pagine: 34 - 38
SICI:
0885-3177(199901)18:1<34:SADOCI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROLONGED ETHANOL INTAKE; RAT PANCREAS; ALCOHOLIC PANCREATITIS; DEGRADING ENZYMES; EXPRESSION; FIBROSIS; MALNUTRITION; PROTEINS; TISSUE;
Keywords:
collagen; collagenase; prolylhydroxylase; fibrogenesis; chronic pancreatitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Navarro, S Univurg,celona, Hosp Clin Barcelona, Dept Med, Inst Malalties Digest,Dept S Univ Barcelona Villarroel 170 Barcelona Spain E-08036 t,Dept S
Citazione:
R. Valderrama et al., "Synthesis and degradation of collagen in pancreatic fibrogenesis", PANCREAS, 18(1), 1999, pp. 34-38

Abstract

The mechanism of fibrogenesis in the pancreas is not well known. We analyzed the role of prolylhydroxylase and collagenase activities in the development of fibrosis in chronic alcoholic pancreatitis (CAP). Nineteen patients with CAP and 11 controls (organ donors) with normal pancreatic histology were included in the study. Pancreatic tissue was obtained from all subjects to measure (a) area of fibrosis (histomorphometric method); (b) prolylhydroxylase activity (PHase), which reflects the intracellular synthesis of collagen (Hutton's method); and (c) collagenase activity, which reflects the degradation of collagen (collagenase assay system, H-3). The percentage of the fibrosis area in relation to the total area of pancreatic tissue was significantly higher in CAP than in the control group (70.6 +/- 20.2% vs. 4.6 +/- 1.8%; p < 0.001). Mean pancreatic PHase activity was also significantly higher in CAP than in the control group (775 +/- 258 cpm/mg protein/h vs. 405 +/- 151 cpm/mg protein/h; p < 0.001), The collagenase activity was significantly lower in CAP than in the control group (8.7 +/- 3.5 cpm/cpm added/mg protein vs. 18.0 +/- 3.9 cpm/cpm added/mg protein; p < 0.001). A significant correlation was observed between percentage fibrosis evaluated histomorphometrically and PHase activity in all patients (r = 0.72; p < 0.001), and between PHase and collagenase activities in controls (r = 0.70; p = 0.024), but not in CAP. Pancreatic tissue in CAP has an increased fibrogenic activity and an impaired collagen-degradation capacity. These findings might explain the excessive development of fibrosis in CAP.

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Documento generato il 04/12/20 alle ore 21:22:40