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Titolo:
Evaluation of behavioural effects of neural melanocortin receptor antagonists injected ICV and in VTA in rats
Autore:
Klusa, V; Svirskis, S; Opmane, B; Muceniece, R; Skujins, A; Mutulis, F; Wikberg, JES; Schioth, HB;
Indirizzi:
UppsalanUniv, Ctr Biomed, Dept Pharmaceut Pharmacol, S-75124 Uppsala, Swede Uppsala Univ Uppsala Sweden S-75124 ut Pharmacol, S-75124 Uppsala, Swede Latvian Inst Organ Synth, Pharmacol Lab, Riga, Latvia Latvian Inst Organ Synth Riga Latvia Synth, Pharmacol Lab, Riga, Latvia
Titolo Testata:
NEUROPEPTIDES
fascicolo: 6, volume: 32, anno: 1998,
pagine: 573 - 580
SICI:
0143-4179(199812)32:6<573:EOBEON>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; RADIOLIGAND BINDING; ACTH RECEPTOR; ALPHA-MSH; EXPRESSION; LOCALIZATION; IDENTIFICATION; MELANOTROPIN; SELECTIVITY; PEPTIDES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Schioth, HB Uppsalala,iv, Ctr Biomed, Dept Pharmaceut Pharmacol, Box 591, S-75124 Uppsa Uppsala Univ Box 591 Uppsala Sweden S-75124 91, S-75124 Uppsa
Citazione:
V. Klusa et al., "Evaluation of behavioural effects of neural melanocortin receptor antagonists injected ICV and in VTA in rats", NEUROPEPTID, 32(6), 1998, pp. 573-580

Abstract

The natural melanocortic peptides are known to exert a variety of effects after central administration. Recently, we discovered the first potent and selective substances for the MC4 receptor, i.e. HS964 and HS014. We found HS964 to be an antagonist for the MC1, MC3, MC4 and MC5 receptors in vitro. HS014 is an antagonist for the MC3 and MC4 receptors and a partial antagonist for the MC1 and MC5 receptors. We injected alpha-MSH and these substances, both intracerebroventricular (ICV) and in the ventral tegmental area (VTA) in rats and scored several behavioural effects. The results show that alpha-MSH caused intensive grooming which was antagonized by pre-treatment ofboth HS014 and HS964. The data give further support to the hypothesis thatit is the MC4 receptor which mediates grooming in rodents. The grooming effects of alpha-MSH were more pronounced after intra-VTA administration compared to the ICV administration. Both alpha-MSH, HS014 and HS964 caused an increase in vertical activity of the rats after intra-VTA administration butnot after ICV administration. Horizontal activity was virtually not affected by the administration of the peptides. The data indicate that the neuralMC3 and MC4 receptors are not likely to be an important mediators of locomotor activity in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:27:20