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Titolo:
Changes with age in the modulation of natural killer activity of murine leukocytes by gastrin releasing peptide, neuropeptide Y and sulfated cholecystokinin octapeptide
Autore:
Medina, S; Del Rio, M; Ferrandez, MD; Hernanz, A; De la Fuente, M;
Indirizzi:
Univ-28040utense Madrid, Fac Ciencias Biol, Dept Biol Anim Fisiol Anim 2, E Univ Complutense Madrid Madrid Spain E-28040 Biol Anim Fisiol Anim 2, E Hosp La Paz Insalud, Serv Bioquim, Madrid, Spain Hosp La Paz Insalud Madrid Spain z Insalud, Serv Bioquim, Madrid, Spain
Titolo Testata:
NEUROPEPTIDES
fascicolo: 6, volume: 32, anno: 1998,
pagine: 549 - 555
SICI:
0143-4179(199812)32:6<549:CWAITM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; PROTEIN-KINASE-C; PERITONEAL MACROPHAGE FUNCTIONS; VASOACTIVE-INTESTINAL-PEPTIDE; CELLULAR CYTO-TOXICITY; NEUROMEDIN-C; LYMPHOCYTE SUBSETS; CYTOTOXIC ACTIVITY; PERIPHERAL-BLOOD; FACTOR-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: De la Fuente, M Univ-28040utense Madrid, Fac Ciencias Biol, Dept Biol AnimFisiol Anim 2, E Univ Complutense Madrid Madrid Spain E-28040 l Anim 2, E
Citazione:
S. Medina et al., "Changes with age in the modulation of natural killer activity of murine leukocytes by gastrin releasing peptide, neuropeptide Y and sulfated cholecystokinin octapeptide", NEUROPEPTID, 32(6), 1998, pp. 549-555

Abstract

Several investigations have suggested that the interactions between the nervous and immune systems are modified with age. The aim of the present workwas to study the effect of three neuropeptides: gastrin-releasing peptide (GRP), neuropeptide Y (NPY) and sulfated cholecystokinin octapeptide (CCK-8s) on natural killer (NK) activity of spleen, thymus and axillary node leukocytes from BALB/c male, young (8 +/- 1 weeks), adult (24 +/- 2 weeks) andold (72 +/- 2 weeks) mice. We used cells from murine lymphoma YAC-1 as targets for the cytotoxic assay and three physiological concentrations of the neuropeptides (10(-8), 10(-10) and 10(-12) M). In control samples, in the absence of neuropeptide, we observed a decreased NK activity in young and old mice with respect to the adults in the three organs studied. Regarding the effect of the neuropeptides, GRP stimulates the cytotoxic activity of leukocytes from all locations, in adult animals. At the same age, NPY also stimulates the NK activity of leukocytes from axillary nodes and thymus, whereas it decreases the NK activity of spleen leukocytes from young mice, CCK-8s has an inhibitory effect on the axillary node leukocytes from young miceand spleen leukocytes from old animals. However, CCK-8 s increased the NK activity of thymus leukocytes from young and adult mice. The results indicate that the highest values of NK activity are found in adult mice, and thatthe stimulating effect of the three neuropeptides studied on NK activity of leukocytes from adult mice are reduced or disappeared, in general, in oldas well as in young animals, Furthermore, the changes observed with ageingin the modulation of NK activity by the neuropeptides studied suggest an altered integration of the nervous and immune systems.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 10:50:02