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Titolo:
Effects of a tachykinin NK3 receptor antagonist, SR 142801, studied in isolated neonatal rat spinal cord
Autore:
Guo, JZ; Yoshioka, K; Otsuka, M;
Indirizzi:
Tokyo Med & Dent Univ, Fac Med, Dept Pharmacol, Tokyo 113, Japan Tokyo Med& Dent Univ Tokyo Japan 113 , Dept Pharmacol, Tokyo 113, Japan Tokyo Med & Dent Univ, Fac Med, Div Sci Lab, Tokyo 113, Japan Tokyo Med & Dent Univ Tokyo Japan 113 Med, Div Sci Lab, Tokyo 113, Japan
Titolo Testata:
NEUROPEPTIDES
fascicolo: 6, volume: 32, anno: 1998,
pagine: 537 - 542
SICI:
0143-4179(199812)32:6<537:EOATNR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUBSTANCE-P; NOCICEPTIVE REFLEX; BINDING-SITES; NEWBORN RAT; MOTONEURONS; NEUROTRANSMITTER; STIMULATION; ONTOGENY; AGONISTS; ROOTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Guo, JZ Georgeashington,n Univ, Med Ctr, Dept Pharmacol, 2300 Eye St NW,Room 640, W George Washington Univ 2300 Eye St NW,Room 640 Washington DC USA 20037
Citazione:
J.Z. Guo et al., "Effects of a tachykinin NK3 receptor antagonist, SR 142801, studied in isolated neonatal rat spinal cord", NEUROPEPTID, 32(6), 1998, pp. 537-542

Abstract

Effects of a nonpeptide tachykinin NK3 receptor antagonist, SR 142801,werestudied in the isolated spinal cord preparation of the neonatal rat. Potential changes were recorded extracellularly from a lumbar ventral root. Bath-application of neurokinin B induced a dose-dependent depolarization of theventral root. SR 142801 caused rightward shifts of the concentration-response curve for neurokinin B with pA(2) of 6.57, but did not affect the depolarizing responses to other agonists. Stimulation of a dorsal root evoked inthe ipsilateral ventral root of the same segment monosynaptic and polysynaptic reflexes of fast time course which were followed by a slow depolarization (ipsilateral slow ventral root potential). SR 142801 depressed the ipsilateral slow ventral root potential. The present results indicate that SR 142801 is a specific antagonist for tachykinin NK, receptors in the spinal cord and suggest that NK, receptors are involved in primary afferent-evoked nociceptive responses of spinal neurones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:51:50