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Titolo:
Acute effects of acetyl-L-carnitine on sodium cyanide-induced behavioral and biochemical deficits
Autore:
Prickaerts, J; Blokland, A; Bothmer, J; Honig, W; Markerink-Van Ittersum, M; Jolles, J;
Indirizzi:
Maastrichtchol,, European Grad Sch Neurosci EURON, Dept Psychiat & Neuropsy Maastricht Univ Maastricht Netherlands NL-6200 MD pt Psychiat & Neuropsy Maastricht Univ, European Grad Sch Neurosci EURON, Dept Psychol, NL-6200 MD Maastricht Univ Maastricht Netherlands NL-6200 MD pt Psychol, NL-6200 MD
Titolo Testata:
NEUROCHEMISTRY INTERNATIONAL
fascicolo: 5, volume: 33, anno: 1998,
pagine: 435 - 443
SICI:
0197-0186(199811)33:5<435:AEOAOS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL MITOCHONDRIAL POPULATIONS; CANINE NEUROLOGICAL INJURY; BRAIN ENERGY-METABOLISM; H-1-NMR SPECTROSCOPY; ALZHEIMERS-DISEASE; L-ACETYLCARNITINE; RAT-BRAIN; AGED RATS; ACETYL-1-CARNITINE; HYPOGLYCEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Prickaerts, J Maastrichtchol,, European Grad Sch Neurosci EURON, Dept Psychiat & Neuropsy Maastricht Univ POB 616 Maastricht Netherlands NL-6200 MD y
Citazione:
J. Prickaerts et al., "Acute effects of acetyl-L-carnitine on sodium cyanide-induced behavioral and biochemical deficits", NEUROCHEM I, 33(5), 1998, pp. 435-443

Abstract

In the present study we investigated the effects of acute treatment with acetyl-L-carnitine (50 mg/kg, i.v. 90 min before the sodium cyanide injection) on a sodium cyanide-induced behavioral deficit in the Morris water escape task. In a first experiment the spatial discrimination performance of therats was found to be dose-dependently impaired after an i.c.v. injection of sodium cyanide (2.5 and 5.0 mu g). Acute treatment with acetyl-L-carnitine was found to increase the behavioral deficit after sodium cyanide, these findings were replicated in a second experiment. Based on these results it can be argued that an acute administration of acetyl-L-carnitine appears topotentiate a sodium cyanide-induced behavioral deficit. An additional in vitro experiment with rat brain synaptosomes showed clear effects of administered sodium cyanide on the energy-dependent incorporation of inositol intophosphoinositides and on the ATP concentration. In vitro acetyl-L-carnitine administration had no effect on the sodium cyanide-induced energy depletion. The negative behavioral findings are in contrast with our previously found protective effect of chronic treatment with acetyl-L-carnitine (via drinking water) on the sodium cyanide-induced behavioral deficit. Since chronic acetyl-L-carnitine treatment has no effect on the phosphoinositide metabolism it was suggested that acetyl-L-carnitine may act via the formation of an ATP-independent reservoir of activated acyl groups. Thus, fatty acids asacylated derivatives can be used for reacylation processes during an acuteperiod of energy depletion. However, we have no clear explanation for the discrepancy in behavioral results between the chronic vs acute treatment ofacetyl-L-carnitine at present. Further research is needed to characterize the mechanism of action of acetyl-L-carnitine in relation to sodium cyanide. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:16:31