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Titolo:
Endocrine aspects of ageing in the male
Autore:
Gooren, LJG;
Indirizzi:
Freesterdam,sterdam Hosp, Dept Endocrinol, Androl Unit, AZVU, NL-1007 MB Am Free Univ Amsterdam Hosp Amsterdam Netherlands NL-1007 MB NL-1007 MB Am
Titolo Testata:
MOLECULAR AND CELLULAR ENDOCRINOLOGY
fascicolo: 1-2, volume: 145, anno: 1998,
pagine: 153 - 159
SICI:
0303-7207(19981025)145:1-2<153:EAOAIT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTATE-SPECIFIC ANTIGEN; MIDDLE-AGED MEN; TESTOSTERONE REPLACEMENT; SERUM TESTOSTERONE; MALE CONTRACEPTION; HYPOGONADAL MALES; REFERENCE RANGES; BONE-DENSITY; SEX-HORMONES; OLDER MEN;
Keywords:
ageing; man; testosterone; prostate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Gooren, LJG Free1007v Amsterdam Hosp, Dept Endocrinol, Androl Unit, AZVU, POB 7057, NL- Free Univ Amsterdam Hosp POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
L.J.G. Gooren, "Endocrine aspects of ageing in the male", MOL C ENDOC, 145(1-2), 1998, pp. 153-159

Abstract

There is a statistical decline of testosterone levels in ageing men, most manifest in free testosterone. While this fall is only moderate, ageing menshow clinical signs of hypogonadism (loss of muscle mass/strength, reduction in bone mass and an increase in visceral fat). This might represent not only a fall but (also) an impairment of the biological action of androgens in target organs. The first small scale studies of androgen supplement administration in ageing men were not disappointing. Anticipated risks lie withthe prostate and the cardiovascular system. The risks with regard to prostate disease are often over-rated. The question remains how the segment of the ageing male population possibly benefiting from androgen supplements, can be identified. For the treatment of postmenopausal women 'designer oestrogens' are being developed; similarly, designer androgens retaining beneficial anabolic effects with elimination of harmful effects on the prostate andcardiovascular system, could be devised. (C) 1998 Elsevier Science IrelandLtd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 18:23:59