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Titolo:
Effects of endotoxic shock in several functions of murine peritoneal macrophages
Autore:
Victor, VM; Minano, M; Guayerbas, N; Del Rio, M; Medina, S; De la Fuente, M;
Indirizzi:
Univ Complutense Madrid, Fac Biol, Dept Fisiol Anim, E-28040 Madrid, SpainUniv Complutense Madrid Madrid Spain E-28040 Anim, E-28040 Madrid, Spain
Titolo Testata:
MOLECULAR AND CELLULAR BIOCHEMISTRY
fascicolo: 1-2, volume: 189, anno: 1998,
pagine: 25 - 31
SICI:
0300-8177(199812)189:1-2<25:EOESIS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; LIPID PEROXIDES; FACTOR-ALPHA; TNF-ALPHA; SUPEROXIDE; MODULATION; ADHERENCE; INFLAMMATION; MEDIATOR; PEPTIDE;
Keywords:
endotoxic shock; macrophages; phagocytic functions; mice; LPS; superoxide anion;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: De la Fuente, M Univd,omplutense Madrid, Fac Ciencias Biol, Dept Fisiol Anim, E-28040 Madri Univ Complutense Madrid Madrid Spain E-28040 28040 Madri
Citazione:
V.M. Victor et al., "Effects of endotoxic shock in several functions of murine peritoneal macrophages", MOL C BIOCH, 189(1-2), 1998, pp. 25-31

Abstract

Gram negative sepsis and septic shock continue to be a major medical problem, with a complex physiopathology and it is associated with high mortality. Although secretion of cytokines such as tumor necrosis factor-alpha by macrophages is the principal host mediator of septic shock, other characteristic functions of macrophages implicated in their phagocytic capacity have not been studied in the process of endotoxic shock. In the present study we have used an intraperitoneal injection of E. coli lipopolysaccharide (LPS) (100 mg/kg) in order to obtain an endotoxic shock model in adult female BALB/c mice. Peritoneal cell suspensions were obtained at several times (2, 4,12 or 24 h) after injection and the following functions were studied on the peritoneal macrophages: adherence to substrate, mobility (spontaneous anddirected or chemotaxis), ingestion of particles and superoxide anion production. The results showed a stimulation of adherence, ingestion and superoxide production as well as a decrease of chemotaxis in the animals injected with LPS. These effects changed with time after LPS injection. Thus, the increase of adherence and the decrease of mobility were higher during the first hours, whereas the increase in ingestion and superoxide production turned larger with time.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:01:00