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Titolo:
ANGIOTENSIN II-INDUCED AND IV-INDUCED CHANGES IN CEREBRAL BLOOD-FLOW ROLES OF AT(1) AT(2), AND AT(4) RECEPTOR SUBTYPES
Autore:
KRAMAR EA; HARDING JW; WRIGHT JW;
Indirizzi:
WASHINGTON STATE UNIV,DEPT PSYCHOL & VET & COMPARAT ANAT,PROGRAM NEUROSCI PULLMAN WA 99164 WASHINGTON STATE UNIV,DEPT PSYCHOL & VET & COMPARAT ANAT,PROGRAM NEUROSCI PULLMAN WA 99164 WASHINGTON STATE UNIV,DEPT PHARMACOL PULLMAN WA 99164 WASHINGTON STATE UNIV,DEPT PHYSIOL PULLMAN WA 99164
Titolo Testata:
Regulatory peptides
fascicolo: 2, volume: 68, anno: 1997,
pagine: 131 - 138
SICI:
0167-0115(1997)68:2<131:AIAICI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT DILATION; RABBIT BRAIN ARTERIOLES; BINDING-SITE; SELECTIVE VULNERABILITY; HIPPOCAMPUS; RAT; IDENTIFICATION; MEMORY; VASODILATION; ISCHEMIA;
Keywords:
LASER-DOPPLER FLOWMETRY; CEREBRAL MICROCIRCULATION; DUP 753; PD123177; DIVALINAL-ANGIV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
E.A. Kramar et al., "ANGIOTENSIN II-INDUCED AND IV-INDUCED CHANGES IN CEREBRAL BLOOD-FLOW ROLES OF AT(1) AT(2), AND AT(4) RECEPTOR SUBTYPES", Regulatory peptides, 68(2), 1997, pp. 131-138

Abstract

Our laboratory has previously reported the discovery of a unique angiotensin binding site (termed AT(4)) specific for angiotensin IV (AngIV) in cultured vascular endothelial and smooth muscle cells. The present investigation employed laser-Doppler flowmetry to examine the effectof angiotensin II (AngII) and AngIV stimulation of these receptors oncerebral microcirculation in anesthetized Sprague-Dawley rats. Internal carotid artery infusion of AngII al a low dose (0.1 pmol min(-1)) revealed a 23% reduction in cerebral blood flow (CBF), while the infusion of AngIV increased CBF ir. a dose-dependent fashion with the highest dose (100 pmol min(-1)) resulting in an elevation of 30%. In a second experiment separate groups of rats were pre-treated with the AT(1) receptor subtype antagonist DuP 753 (Losartan), the AT(2) receptor subtype antagonist PD123177, or a newly synthesized AT(4) receptor subtypeantagonist Divalinal-AngIV (Divalinal), followed by AngII or AngIV for the purpose of determining which angiotensin receptor subtype is responsible for mediating these AngII- and AngIV-induced responses. Pre-treatment with Losartan completely blocked subsequent AngII-induced reductions in CBF, while both PD123177 and Divalinal failed to inhibit this response. In contrast, significant increases in CBF were measured due to AngIV stimulation following pre-treatment with Losartan and PD123177, while Divalinal abolished this AngIV-induced response. These results suggest that AngII and IV play opposite roles in cerebral microcirculation, i.e., the AT(1) receptor subtype mediates AngII-induced reductions in CBF, while the AT(4) receptor subtype regulates increases in CBF. (C) 1997 Elsevier Science B.V.

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Documento generato il 04/04/20 alle ore 10:50:08