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Titolo:
Environmental control of collateral branching and target invasion of mitral cell axons during development
Autore:
Hirata, T; Fujisawa, H;
Indirizzi:
Nagoya Univ, Grad Sch Sci, Div Biol Sci, Chikusa Ku, Nagoya, Aichi 4648602, Nagoya Univ Nagoya Aichi Japan 4648602 Chikusa Ku, Nagoya, Aichi 4648602,
Titolo Testata:
JOURNAL OF NEUROBIOLOGY
fascicolo: 1, volume: 38, anno: 1999,
pagine: 93 - 104
SICI:
0022-3034(199901)38:1<93:ECOCBA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLLAPSIN-1 MESSENGER-RNA; MEMBRANE-BOUND MOLECULES; SOMATIC SENSORY CORTEX; OLFACTORY-BULB; SEMAPHORIN-III; NERVOUS-SYSTEM; POSTNATAL-DEVELOPMENT; RAT; GROWTH; CONNECTIONS;
Keywords:
mitral cell; collateral branch; primary axon; target invasion; waiting period;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Hirata, T Nagoya Univ, Grad Sch Sci, Div Biol Sci, Chikusa Ku, Nagoya, Aichi 4648602, Nagoya Univ Nagoya Aichi Japan 4648602 , Nagoya, Aichi 4648602,
Citazione:
T. Hirata e H. Fujisawa, "Environmental control of collateral branching and target invasion of mitral cell axons during development", J NEUROBIOL, 38(1), 1999, pp. 93-104

Abstract

During development, mitral cell axons, the major efferents of the olfactory bulb, exhibit a protracted waiting period in the lateral olfactory tract (LOT) before giving off collateral branches and innervating the target olfactory cortex, To investigate the target invasion mechanism, a series of heterochronic and heterotopic cocultures of olfactory bulbs with various olfactory cortical strips were conducted. These experiments indicated that development of collateral branches is triggered by environmental cues but not byintrinsic mechanisms in mitral cells. The collateral-inducing cues are apparently different from the cues directing outgrowth of primary mitral cell axons. Coculture experiments also indicated that the target olfactory cortex undergoes a developmental change to become accessible to mitral cell fibers. Primary mitral cell axons, however, still preferred the LOT position over such accessible piriform cortex when encountered both the locations. These results suggest that mitral cell projection comprises multiple steps which are controlled by various environmental cues, (C) 1999 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 12:11:45