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Titolo:
Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells
Autore:
Bebo, BF; Schuster, JC; Vandenbark, AA; Offner, H;
Indirizzi:
Dept Vet Affairs, Portland, OR 97201 USA Dept Vet Affairs Portland OR USA97201 et Affairs, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Neurol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 Neurol, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97201 USAOregon Hlth Sci Univ Portland OR USA 97201 mmunol, Portland, OR 97201 USA
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 1, volume: 162, anno: 1999,
pagine: 35 - 40
SICI:
0022-1767(19990101)162:1<35:AATCPA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS; IMMUNE-RESPONSE; LEWIS RAT; MICE; PREGNANCY; ESTROGEN; DISEASE; MACROPHAGES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Bebo, BF Dept Vet Affairs, 3710 SW US Vet Hosp Rd, Portland, OR 97201 USA Dept Vet Affairs 3710 SW US Vet Hosp Rd Portland OR USA 97201 USA
Citazione:
B.F. Bebo et al., "Androgens alter the cytokine profile and reduce encephalitogenicity of myelin-reactive T cells", J IMMUNOL, 162(1), 1999, pp. 35-40

Abstract

Adoptive transfer of proteolipid protein 139-151-specific T cell lines wasused to examine the role of androgens in regulating T cell cytokine secretion and the severity of experimental autoimmune encephalomyelitis (EAE) in the SJL mouse, In this study, we found that T cells from female mice transferred more severe EAE than T cells from male mice and that gender differences in clinical disease were due, at least in part, to differences in donor T cell cytokine secretion. T cell lines were selected from proteolipid protein 139-151-immunized female SJL mice in the presence or absence of exogenous androgens, Androgen-selected T cell lines secreted less IFN-gamma and more IL-10 than untreated cell lines. Clinical disease induced by the adoptive transfer of androgen-selected T cell lines was less severe than disease induced with untreated T cell lines. Furthermore, androgen treatment of naive TCR transgenic T cells, during their first encounter with Ag, resulted ina shift in the balance of Th1/Th2 cytokines, This phenotype was maintainedduring subsequent stimulations in the absence of androgen, These results suggest that androgen present in the lymphoid microenvironment during the induction of an immune response can alter the development of effector T cellsand may play an important role in governing gender differences in the immune response and susceptibility to autoimmune disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:19:19