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Titolo:
CADASIL syndrome: A genetic form of vascular dementia
Autore:
Salloway, S; Hong, J;
Indirizzi:
Butler Hosp, Providence, RI 02906 USA Butler Hosp Providence RI USA 02906Butler Hosp, Providence, RI 02906 USA Browne,niv, Sch Med, Dept Clin Neurosci & Psychiat & Human Behav, Providenc Brown Univ Providence RI USA 02912 ci & Psychiat & Human Behav, Providenc
Titolo Testata:
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
fascicolo: 2, volume: 11, anno: 1998,
pagine: 71 - 77
SICI:
0891-9887(199822)11:2<71:CSAGFO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOSOMAL-DOMINANT ARTERIOPATHY; MULTI-INFARCT DEMENTIA; NOTCH3 MUTATIONS; SUBCORTICAL INFARCTS; LEUKOENCEPHALOPATHY; DISEASE; STROKE; ENCEPHALOPATHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Salloway, S Butler Hosp, 345 Blackstone Blvd, Providence, RI 02906 USA Butler Hosp 345 Blackstone Blvd Providence RI USA 02906 06 USA
Citazione:
S. Salloway e J. Hong, "CADASIL syndrome: A genetic form of vascular dementia", J GER PSY N, 11(2), 1998, pp. 71-77

Abstract

Mental disorders due to cerebral microvascular disease have been known forover 100 years. Recently, an autosomal dominant form of cerebral arteriopathy (CADASIL) has been described in association with a Notch3 family gene on the short arm of chromosome 19. CADASIL causes subcortical lacunar infarction and dementia in over 80% of cases and depression in a large proportionof patients. Clinically, CADASIL may appear to be very similar to hypertensive microvascular disease (Binswanger's disease), a condition that is seenin the elderly. This article reviews the clinical, pathologic, and geneticfeatures of CADASIL. CADASIL is of interest to neurologists and psychiatrists because it is the first syndrome of vascular dementia and depression with an identified gene. How the gene causes the widespread arteriopathy is not yet known. Insights gained from the study of CADASIL should help us better understand its etiology, as well as the options for treatment of the more common forms of microvascular disease seen in the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:12:41