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Titolo:
Aged gastric mucosa: Mechanisms of vulnerability
Autore:
Malcontenti-Wilson, C; Schulz, S; Penney, AG; Andrews, FJ; OBrien, PE;
Indirizzi:
MonashaUniv, Alfred Hosp, Sch Med, Dept Surg, Melbourne, Vic 3181, Australi Monash Univ Melbourne Vic Australia 3181 g, Melbourne, Vic 3181, Australi
Titolo Testata:
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
, volume: 13, anno: 1998, supplemento:, 2
pagine: S204 - S208
SICI:
0815-9319(199811)13:<S204:AGMMOV>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; GASTROINTESTINAL-TRACT; AGING RATS; ASPIRIN; ADAPTATION; INJURY; HUMANS; L-745,337; INHIBITOR; TOXICITY;
Keywords:
adaptation; aged; cyclooxygenase-2 inhibitors; gastrotoxicity; non-steroidal antiinflammatory drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: O'Brien, PE MonashaUniv, Alfred Hosp, Sch Med, Dept Surg, Melbourne, Vic 3181, Australi Monash Univ Melbourne Vic Australia 3181 , Vic 3181, Australi
Citazione:
C. Malcontenti-Wilson et al., "Aged gastric mucosa: Mechanisms of vulnerability", J GASTR HEP, 13, 1998, pp. S204-S208

Abstract

The incidence, frequency of complications and mortality of gastric ulcer disease are increased four-fold in the elderly taking non-steroidal anti-inflammatory drugs (NSAID). There is controversy as to whether this reflects increased usage of NSAID or specific vulnerability associated with age. We have investigated two possible mechanisms for this increase in gastrointestinal effects in the elderly: (i) increased susceptibility to acute gastrotoxicity; and (ii) reduced adaptation to NSAID, in a model of young (2 month),mature (12 month) and aged (24 month) rats. Aspirin damaged 7.7% of the volume of gastric mucosa in the young rat. In mature and aged rats, this increased to 11.3% (P < 0.002 compared to control) and 21.9% (P < 0.005 compared to control), respectively. Thus, aspirin caused a three-fold increase in the severity of acute gastric mucosal injury in aged animals. However, indomethacin, ibuprofen and L745 337 did not produce any significant acute gastric mucosal damage in 2-, 12- or 24-month-old rats. Significant gastric adaptation to diclofenac treatment occurred in both aged and young rats as measured by gastric mucosal damage. The aged gastric mucosa adapted equally aswell as the young gastric mucosa to diclofenac. The findings of this studyprovide only modest support to the hypothesis of increased vulnerability of the stomach in the aged. Aspirin was associated with greater damage in the aged. Adaptation to diclofenac-induced damage was not reduced in the agedand there was not an increased susceptibility to damage by the non-aspirinNSAID tested. The selective cyclo-oxygenase-2 inhibitor, L745 337, was theleast toxic agent and may represent a group of NSAID which cause fewer gastrointestinal complications in the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:52:43