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Titolo:
Analytical method for the determination of sphinganine and sphingosine in serum as a potential biomarker for fumonisin exposure
Autore:
Castegnaro, M; Garren, L; Galendo, D; Gelderblom, WCA; Chelule, P; Dutton, MF; Wild, CP;
Indirizzi:
Int Agcy Res Canc, Unit Gene Environm Interact, F-69372 Lyon 08, France Int Agcy Res Canc Lyon France 08 ironm Interact, F-69372 Lyon 08, France Sg,frican MRC, Programme Mycotoxins & Expt Carcinogenesis, ZA-7505 Tygerber S African MRC Tygerberg South Africa ZA-7505 nogenesis, ZA-7505 Tygerber Univ Natal, Fac Med, Dept Physiol, ZA-4013 Congella, South Africa Univ Natal Congella South Africa ZA-4013 ZA-4013 Congella, South Africa UnivdLeeds, Sch Med, Mol Epidemiol Unit, Leeds LS2 9JT, W Yorkshire, Englan Univ Leeds Leeds W Yorkshire England LS2 9JT LS2 9JT, W Yorkshire, Englan
Titolo Testata:
JOURNAL OF CHROMATOGRAPHY B
fascicolo: 1-2, volume: 720, anno: 1998,
pagine: 15 - 24
SICI:
1387-2273(199812)720:1-2<15:AMFTDO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONILIFORME CULTURE MATERIAL; VIRUS TRANSGENIC MICE; FUSARIUM-MONILIFORME; SPHINGOLIPID METABOLISM; MYCOTOXINS; DISRUPTION; LIVER; RATIO; URINE; CORN;
Keywords:
biomarker; sphinganine; sphingosine; fumonisins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Castegnaro, M Int69372 Res Canc, Unit Gene Environm Interact, 150 Cours Albert Thomas, F- Int Agcy Res Canc 150 Cours Albert Thomas Lyon France 08 F-
Citazione:
M. Castegnaro et al., "Analytical method for the determination of sphinganine and sphingosine in serum as a potential biomarker for fumonisin exposure", J CHROMAT B, 720(1-2), 1998, pp. 15-24

Abstract

The toxins produced by Fusarium moniliforme, which include fumonisins, arepossible human carcinogens. Fumonisins are inhibitors of de novo sphingolipid biosynthesis. Alterations of the ratio of sphinganine (Sa) to sphingosine (So) in urine and serum has been proposed as a possible biomarker of exposure to this toxin. A new method was developed for their analysis in tissues and urine. This work describes the further adaptation of the method to the analysis of Sa and So in serum and its validation in sera of untreated and fumonisin B-1 (FB1) treated rats and mice. No significant differences inthe Sa/So ratios were observed in the FB, treated rats. In mice, the increase was only of marginal statistical significance. Determination of Sa/So ratios in human sera could readily be made in small volumes (from 0.3 to 0.5ml) of serum. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:58:08