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Titolo:
Familial resemblance of bone mineral density (BMD) and calcaneal ultrasound attenuation: The BMD in mothers and daughters study
Autore:
Danielson, ME; Cauley, JA; Baker, CE; Newman, AB; Dorman, JS; Towers, JD; Kuller, LH;
Indirizzi:
UnivSAittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15261 U Univ Pittsburgh Pittsburgh PA USA 15261 Epidemiol, Pittsburgh, PA 15261 U Univ Pittsburgh, Dept Educ Psychol, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA Dept Educ Psychol, Pittsburgh, PA USA Univ Pittsburgh, Dept Geriatr Med, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA , Dept Geriatr Med, Pittsburgh, PA USA Univ Pittsburgh, Dept Radiol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Radiol, Pittsburgh, PA 15260 USA
Titolo Testata:
JOURNAL OF BONE AND MINERAL RESEARCH
fascicolo: 1, volume: 14, anno: 1999,
pagine: 102 - 110
SICI:
0884-0431(199901)14:1<102:FROBMD>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREDICT HIP FRACTURE; PHYSICAL-ACTIVITY; POSTMENOPAUSAL TWINS; GENETIC INFLUENCE; ELDERLY WOMEN; RISK-FACTORS; MASS; OSTEOPOROSIS; AGE; HERITABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Danielson, ME Univrgh,tsburgh, Grad Sch Publ Hlth, Dept Epidemiol, 130 DeSoto St, Pittsbu Univ Pittsburgh 130 DeSoto St Pittsburgh PA USA 15261 ittsbu
Citazione:
M.E. Danielson et al., "Familial resemblance of bone mineral density (BMD) and calcaneal ultrasound attenuation: The BMD in mothers and daughters study", J BONE MIN, 14(1), 1999, pp. 102-110

Abstract

The familial resemblance in bone mineral density (BMD) and calcaneal broadband ultrasound attenuation (BUA) was examined in 207 mother-daughter pairs. Mothers were participants in the Study of Osteoporotic Fractures. Three groups of daughters were recruited based on their maternal history of "fracture," "low BMD" without fracture (< 0.58 g/cm(2), t-score < -2.5), and "normal BMD" without fracture (> 0.67 g/cm(2), t-score > -1.6), Data on other potentially heritable factors known to influence BMD and BUA were also collected. BMD was measured at the hip, spine, whole body, and calcaneus, Calcaneal BUA was assessed using the Walker-Sonix UBA 575, Total hip and femoral neck BMD were significantly lower (5.0-8.0%, p < 0.017) among daughters, inparticular premenopausal daughters, of mothers with established osteoporosis ("fracture" or "low BMD") compared with daughters of mothers at lower risk of osteoporosis ("normal BMD"), BUA did not differ across daughter groups. Lifestyle characteristics (dietary calcium, smoking, physical activity) were not highly correlated in mothers and daughters. Height, weight, and body composition were significantly correlated within mother-daughter pairs and could be a potential mechanism by which BMD is inherited. Among pre- andpostmenopausal daughters, heritability estimates ranged from 50-63% and 34-48%, respectively. Heritability for calcaneal BUA (53%) was evident among postmenopausal daughters only. In conclusion, familial association in BMD was strongest among premenopausal daughters. Estimates of heritability suggest that maternal BMD and BUA are important independent predictors of BMD and BUA among daughters, reinforcing the importance of prevention and early intervention among women with a positive family history of osteoporosis.

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Documento generato il 27/11/20 alle ore 22:17:25