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Titolo:
Leptin resistance in a polygenic, hyperleptinemic animal model of obesity and NIDDM: Psammomys obesus
Autore:
Walder, K; Lewandowski, P; Morton, G; Sanigorski, A; de Silva, A; Zimmet, P; Collier, GR;
Indirizzi:
Deakin Univ, Sch Nutr & Publ Hlth, Geelong, Vic 3217, Australia Deakin Univ Geelong Vic Australia 3217 Hlth, Geelong, Vic 3217, Australia Int Diabet Inst, Caulfield, Vic 3162, Australia Int Diabet Inst CaulfieldVic Australia 3162 ulfield, Vic 3162, Australia
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 1, volume: 23, anno: 1999,
pagine: 83 - 89
SICI:
0307-0565(199901)23:1<83:LRIAPH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INSULIN-RESISTANCE; GENE; MICE; RECEPTOR; PROTEIN;
Keywords:
Psammomys obesus; obesity treatment; leptin resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Collier, GR Deakinaliav, Sch Nutr & Publ Hlth, Geelong Campus, Geelong, Vic 3217, Austr Deakin Univ Geelong Campus Geelong Vic Australia 3217 7, Austr
Citazione:
K. Walder et al., "Leptin resistance in a polygenic, hyperleptinemic animal model of obesity and NIDDM: Psammomys obesus", INT J OBES, 23(1), 1999, pp. 83-89

Abstract

OBJECTIVE: To investigate the effects of leptin administration to Psammomys obesus, a polygenic animal model of obesity and type 2 diabetes mellitus,DESIGN: Longitudinal intervention study utilising three separate leptin treatment protocols lasting 7-14d,MEASUREMENTS: Body weight and food intake were measured daily, body fat and muscle content were estimated by carcass analysis on completion of the study. Blood glucose, plasma insulin, leptin, triglycerides and cholesterol were measured at baseline and twice each week during the study. RESULTS: Relatively high doses of leptin were required to significantly reduce food intake and body fat content in lean Psammomys obesus, but had no discernible effect on their obese littermates. CONCLUSION: As a species, Psammomys obesus appear to be relatively insensitive to the effects of leptin administration, compared with other rodents. Obese Psammomys obesus are leptin resistant relative to their lean littermates.

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Documento generato il 01/12/20 alle ore 00:51:44