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Titolo:
Plasma soluble endothelial selectin is elevated in women with pre-eclampsia
Autore:
Daniel, Y; Kupferminc, MJ; Baram, A; Jaffa, AJ; Wolman, I; Shenhav, M; Lessing, JB;
Indirizzi:
TelDeptv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, LIS Matern Hosp, Tel Aviv Univ Tel Aviv Israel IL-64239 ourasky Med Ctr, LIS Matern Hosp,
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 12, volume: 13, anno: 1998,
pagine: 3537 - 3541
SICI:
0268-1161(199812)13:12<3537:PSESIE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION MOLECULES; SEVERE PREECLAMPSIA; HUMAN CYTOTROPHOBLASTS; ENDOVASCULAR INVASION; NEUTROPHILS; HYPOTHESIS; PHENOTYPE;
Keywords:
endothelial activation; neutrophil activation; platelet activation; pre-eclampsia; soluble selectins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Lessing, JB TelDeptv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, LISMatern Hosp, Tel Aviv Univ 6 Weizman St Tel Aviv Israel IL-64239 ern Hosp,
Citazione:
Y. Daniel et al., "Plasma soluble endothelial selectin is elevated in women with pre-eclampsia", HUM REPR, 13(12), 1998, pp. 3537-3541

Abstract

The study was conducted to determine whether altered plasma concentrationsof soluble selectins are involved in the pathogenesis of pre-eclampsia, Maternal plasma samples were collected from 20 patients with preeclampsia, and from 20 matched normotensive patients with uncomplicated pregnancies. Samples were assayed for soluble endothelial selectin (sES), platelet selectin(sPS) and leukocyte selectin (sLS) by specific enzyme-linked immunosorbentassay. The three soluble selectins were detectable in the plasma of all pre-eclamptic and control patients. The mean plasma concentrations of sPS andsLS were comparable between the groups. However, the mean plasma concentration of sES was significantly higher in the pre-eclamptic group compared with the control group (61 ng/ml +/- 30 ng/ml compared with 40 ng/ml +/- 17 ng/ml; P < 0.01). The selective increased plasma concentrations of sES in patients with pre-eclampsia provide specific evidence for endothelial activation and may reflect distinct pathways for neutrophil activation in pre-eclampsia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:16:10