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Titolo:
Human chorionic gonadotrophin luteal support overcomes luteal phase inadequacy after gonadotrophin-releasing hormone agonist-induced ovulation in gonadotrophin-stimulated cycles
Autore:
Penarrubia, J; Balasch, J; Fabregues, F; Creus, M; Casamitjana, R; Ballesca, JL; Puerto, B; Vanrell, JA;
Indirizzi:
Univptarcelona, Hosp Clin & Prov, Inst Invest Biomed August Pi & Sunyer, De Univ Barcelona Barcelona Spain E-08036 est Biomed August Pi & Sunyer, De UnivcBarcelona, Hosp Clin & Prov, Inst Invest Biomed August Pi & Sunyer, Fa Univ Barcelona Barcelona Spain E-08036 est Biomed August Pi & Sunyer, Fa
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 12, volume: 13, anno: 1998,
pagine: 3315 - 3318
SICI:
0268-1161(199812)13:12<3315:HCGLSO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIAN HYPERSTIMULATION SYNDROME; LUTEINIZING-HORMONE; INVITRO FERTILIZATION; TRIGGERING OVULATION; INDUCTION; SURGE; PREVENTION; ANALOG; MATURATION;
Keywords:
GnRH agonists; HCG; luteal phase deficiency; ovulation induction; plasma progesterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Balasch, J Univptarcelona, Hosp Clin & Prov, Inst Invest Biomed August Pi & Sunyer, De Univ Barcelona C Casanova 143 Barcelona Spain E-08036 nyer, De
Citazione:
J. Penarrubia et al., "Human chorionic gonadotrophin luteal support overcomes luteal phase inadequacy after gonadotrophin-releasing hormone agonist-induced ovulation in gonadotrophin-stimulated cycles", HUM REPR, 13(12), 1998, pp. 3315-3318

Abstract

Gonadotrophin-releasing hormone agonist (GnRHa)-induced ovulation after gonadotrophin ovarian stimulation is used to prevent ovarian hyperstimulationsyndrome and multiple pregnancy in polyfollicular cycles. However, one of the major problems to be resolved is corpus luteum function after follicular maturation and ovulation by midcycle GnRHa administration. The present report investigated the luteal phase in non-conceptual polyfollicular cycles in 26 patients (group 1) receiving a single dose of 0.5 mg leuprolide acetate to induce ovulation and in a control group of patients (n = 26) (group 2) who were given human chorionic gonadotrophin (HCG) (10 000 IU i.m.) for ovulation induction. All of them were normal ovulatory women undergoing gonadotrophin ovarian stimulation because of unexplained infertility or male factor. In both groups of patients two doses of 2500 IU HCG i.m, were given 6and 10 days after the ovulatory dose of HCG or GnRHa to support the lutealphase. All cycles were ovulatory as shown by mid-luteal serum progesteroneconcentrations >10 ng/ml, Mean serum progesterone concentrations were 62% higher in group 2 than in group 1, but this difference was not statistically significant. The mean length of the luteal phase was similar in groups 1 and 2. It is concluded that HCG luteal support is a useful tool to overcomethe luteal phase inadequacy that characterizes GnRHa-triggered cycles after gonadotrophin stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:14:00