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Titolo:
DISCRIMINATIVE STIMULUS PROPERTIES OF ETHANOL IN THE RAT - EFFECTS OFNEUROSTEROIDS AND PICROTOXIN
Autore:
BIENKOWSKI P; KOSTOWSKI W;
Indirizzi:
INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST,AL SOBIESKIEGO 1-9 PL-02957 WARSAW POLAND INST PSYCHIAT & NEUROL,DEPT PHARMACOL & PHYSIOL NERVOUS SYST PL-02957WARSAW POLAND WARSAW MED UNIV,DEPT CLIN & EXPT PHARMACOL PL-02927 WARSAW POLAND
Titolo Testata:
Brain research
fascicolo: 2, volume: 753, anno: 1997,
pagine: 348 - 352
SICI:
0006-8993(1997)753:2<348:DSPOEI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROACTIVE STEROIDS; DRUG DISCRIMINATION; ION CHANNELS; RECEPTOR; ANTAGONISTS; DEHYDROEPIANDROSTERONE; SUBSTITUTION; POTENTIATION; AGONISTS; MICE;
Keywords:
ETHANOL; GABA(A) RECEPTOR COMPLEX; NEUROSTEROID; PICROTOXIN; DRUG DISCRIMINATION; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
P. Bienkowski e W. Kostowski, "DISCRIMINATIVE STIMULUS PROPERTIES OF ETHANOL IN THE RAT - EFFECTS OFNEUROSTEROIDS AND PICROTOXIN", Brain research, 753(2), 1997, pp. 348-352

Abstract

Tetrahydrodeoxycorticosterone (5 beta-THDOC; 1.3-12.0 mg/kg), a neurosteroid enhancing the GABA(A) receptor-associated chloride conductance, produced predominantly ethanol-appropriate responding (> 80%) in rats trained to discriminate 1.0 g/kg ethanol from saline. However, neither picrotoxin (0.25-1.5 mg/kg), nor dehydroepiandrosterone sulfate (0.01-100.0 mg/kg), a neurosteroid acting as a GABA, receptor antagonist,attenuated the stimulus effects of ethanol. These results indicate that: (1) at least certain neurosteroids may produce subjective states similar to these induced by ethanol; (2) blockade of the GABA(A) receptor-associated channel does not eliminate the ethanol interoceptive cuein rats. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 07:20:07