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Titolo:
CENTRAL CORTICOTROPIN-RELEASING FACTOR AND BENZODIAZEPINE RECEPTOR SYSTEMS ARE INVOLVED IN THE SOCIAL-ISOLATION STRESS-INDUCED DECREASE IN ETHANOL SLEEP IN MICE
Autore:
MATSUMOTO K; OJIMA K; WATANABE H;
Indirizzi:
TOYAMA MED & PHARMACEUT UNIV,RES INST WAKAN YAKU ORIENTAL MED,DEPT PHARMACOL,2630 SUGITANI TOYAMA 93001 JAPAN
Titolo Testata:
Brain research
fascicolo: 2, volume: 753, anno: 1997,
pagine: 318 - 321
SICI:
0006-8993(1997)753:2<318:CCFABR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
GABAERGIC TRANSMISSION; AGGRESSIVE-BEHAVIOR; TRICHLOROETHANOL; MECHANISM; NEURONS; BRAIN;
Keywords:
SOCIAL ISOLATION STRESS; ETHANOL; PENTOBARBITAL; CHLORAL HYDRATE; CRF SYSTEM; GABA(A)/BENZODIAZEPINE RECEPTOR COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
K. Matsumoto et al., "CENTRAL CORTICOTROPIN-RELEASING FACTOR AND BENZODIAZEPINE RECEPTOR SYSTEMS ARE INVOLVED IN THE SOCIAL-ISOLATION STRESS-INDUCED DECREASE IN ETHANOL SLEEP IN MICE", Brain research, 753(2), 1997, pp. 318-321

Abstract

Social isolation stress has been demonstrated to decrease the hypnotic activity of ethanol in rodents. In this study, the role of central corticotropin-releasing factor (CRF) and GABA(A)/benzodiazepine (BZD) receptor systems in the social isolation stress-induced decrease in thehypnotic activity of ethanol in mice was investigated by examining the effect of alpha-helical CRF(9-41) (alpha hCRF) and flumazenil, antagonists of CRF and BZD receptors, respectively, on ethanol-induced sleep in group-housed and socially isolated mice. We also tested whether social isolation stress affects the ability of ethanol to enhance the GABA-induced Cl-36(-) influx into a synaptoneurosomal preparation of mouse forebrain. Social isolation stress significantly decreased both the ethanol (4 g/kg i.p.)-induced and pentobarbital (50 mg/kg i.p.)-induced sleeping times, while this stress had no effect on chloral hydrate(325 mg/kg i.p.)-induced sleep. The i.c.v. injection of alpha hCRF (6.5 nmol) and flumazenil (33 nmol) antagonized the social isolation stress-induced decrease in the ethanol sleep without affecting ethanol sleep in group-housed animals. Social isolation stress significantly attenuated the ability of GABA to stimulate 36 but this stress had no effect on the ability of ethanol to enhance GABA-induced Cl-36(-) influx. These results suggest that the functional changes in central CRF and GABA(A)/BZD receptor systems are involved in the social isolation stress-induced decrease in the hypnotic activity of ethanol in mice. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:51:00