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Titolo:
Butorphanol agonist effects and acute physical dependence in opioid abusers: comparison with morphine
Autore:
Greenwald, MK; Stitzer, ML;
Indirizzi:
Johns Hopkins Univ, Sch Med, Dept Psychiat & Behav Sci, Behav Pharmacol Res Johns Hopkins Univ Baltimore MD USA 21205 Behav Sci, Behav Pharmacol Res
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 1, volume: 53, anno: 1998,
pagine: 17 - 30
SICI:
0376-8716(199812)53:1<17:BAEAAP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISCRIMINATIVE STIMULUS PROPERTIES; NALOXONE-PRECIPITATED WITHDRAWAL; RHESUS-MONKEYS; SQUIRREL-MONKEY; NOR-BINALTORPHIMINE; ANTAGONIST OPIOIDS; KAPPA-RECEPTOR; INTRAVENOUS BUTORPHANOL; DRUG DISCRIMINATION; HEALTHY-VOLUNTEERS;
Keywords:
narcotic dependence; opioid withdrawal; morphine; butorphanol; naloxone; human drug abusers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Greenwald, MK Waynesttate Univ, Sch Med, Dept Psychiat & Behav Neurosci, Clin Res Div Sub Wayne State Univ 2761 E Jefferson Ave Detroit MI USA 48207 b
Citazione:
M.K. Greenwald e M.L. Stitzer, "Butorphanol agonist effects and acute physical dependence in opioid abusers: comparison with morphine", DRUG AL DEP, 53(1), 1998, pp. 17-30

Abstract

This study compared the direct effects and acute physical dependence of butorphanol and morphine, opioids with differing actions at mu versus kappa receptors. Six non-dependent heroin-using volunteers were exposed to six conditions in a within-subject, Latin square design using double-blind procedures. In each session, agonist effects of single i.m. injections of butorphanol (3 and 6 mg/70 kg), morphine (15 and 30 mg/70 kg), lorazepam (4 mg/70 kg) or saline were evaluated. Butorphanol and morphine produced effects of comparable magnitude on miosis and reports of 'any drug effect'. Volunteers reported dysphoria, confusion and sedation after butorphanol, subjective effects that overlapped with those of lorazepam, whereas morphine produced euphoria and stimulation. Acute physical dependence (i.e, precipitated withdrawal responses to naloxone 10 mg/70 kg i.m. administered 6 h after each treatment) significantly increased after 30 mg/70 kg morphine but not after butorphanol treatments. These differences in naloxone sensitivity are likely due to differences in opioid receptor (mu versus kappa) activity, affinity and efficacy of these compounds. Pharmacological ramifications of these results are discussed. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 22:28:20