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Titolo:
Neuroimaging findings in twins discordant for Alzheimer's disease
Autore:
Pedersen, NL; Miller, BL; Wetherell, JL; Vallo, J; Toga, AW; Knutson, N; Mehringer, CM; Small, GW; Gatz, M;
Indirizzi:
Karolinska Inst, Inst Environm Med, S-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-17177 Med, S-17177 Stockholm, Sweden Univ So Calif, Dept Psychol, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 Psychol, Los Angeles, CA 90089 USA Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Radiol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Dept Psychiat, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA Univ Calif Los Angeles, Sch Med, Ctr Aging, Los Angeles, CA USA Univ CalifLos Angeles Los Angeles CA USA Ctr Aging, Los Angeles, CA USA Sonderborg Hosp, Dept Radiol, Sonderborg, Denmark Sonderborg Hosp Sonderborg Denmark sp, Dept Radiol, Sonderborg, Denmark
Titolo Testata:
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
fascicolo: 1, volume: 10, anno: 1999,
pagine: 51 - 58
SICI:
1420-8008(199901/02)10:1<51:NFITDF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL TEMPORAL-LOBE; VASCULAR DEMENTIA; SWEDISH TWINS; ATROPHY; HIPPOCAMPAL; DIAGNOSIS; REGISTRY; RESERVE; ALLELE; BRAIN;
Keywords:
Alzheimer's disease; twins; computed tomography; image processing, computer assisted apolipoprotein E;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Pedersen, NL Karolinska Inst, Inst Environm Med, Box 210, S-17177 Stockholm, Sweden Karolinska Inst Box 210 Stockholm Sweden S-17177 olm, Sweden
Citazione:
N.L. Pedersen et al., "Neuroimaging findings in twins discordant for Alzheimer's disease", DEMENT G C, 10(1), 1999, pp. 51-58

Abstract

Data from computed tomography (CT) scans of 12 twin pairs in which one partner had Azheimer's disease (AD) and the other partner is cognitively intact were analyzed to study structural brain features associated with AD whilecontrolling for familial factors. Visual ratings and analysis of quantified are;as and volumes indicated that AD twins showed more dilation of temporal horns, lateral ventricles and third ventricle, and more atrophy of temporal lobes, particularly in the anterior temporal/peri-sylvian area, than their healthy cotwins. Demented twins did not have smaller intracranial areasor overall brain volumes than their intact partners. The apolipoprotein epsilon-4 allele was associated with greater dilation of lateral ventricles and ventricular volume. Significant intrapair correlations were found for total intracranial area and volume, cerebellar area and white matter lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 23:12:24