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Titolo:
Removal of low-density lipoprotein from plasma by adsorption increases bradykinin and plasma nitric oxide levels in patients with peripheral atherosclerosis
Autore:
Murashima, J; Ueki, Y; Matsunaga, Y; Yano, M; Matsumoto, K; Miyake, S; Tominaga, Y; Eguchi, K; Yano, K;
Indirizzi:
Sasebo Chuo Hosp, Dept Internal Med, Sasebo 8571195, Japan Sasebo Chuo Hosp Sasebo Japan 8571195 nternal Med, Sasebo 8571195, Japan
Titolo Testata:
BLOOD COAGULATION & FIBRINOLYSIS
fascicolo: 8, volume: 9, anno: 1998,
pagine: 725 - 732
SICI:
0957-5235(199811)9:8<725:ROLLFP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DERIVED BRADYKININ; LDL-APHERESIS; DEXTRAN SULFATE; ANAPHYLACTOID REACTIONS; ACE INHIBITORS; RABBIT AORTA; ADHESION; VASODILATATION; CHOLESTEROL; ACTIVATION;
Keywords:
peripheral atherosclerosis; bradykinin; nitric oxide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Ueki, Y Sasebo Chuo Hosp, Dept Internal Med, Yamato Cho 15, Sasebo 8571195, Japan Sasebo Chuo Hosp Yamato Cho 15 Sasebo Japan 8571195 571195, Japan
Citazione:
J. Murashima et al., "Removal of low-density lipoprotein from plasma by adsorption increases bradykinin and plasma nitric oxide levels in patients with peripheral atherosclerosis", BL COAG FIB, 9(8), 1998, pp. 725-732

Abstract

Low-density lipoprotein (LDL) adsorption using a dextran sulfate cellulosecolumn is brought about by electrostatic binding between the positive charges of apolipoprotein B in LDL and the negative charges of dextran sulfate cellulose. There is general agreement that the initial contact phase in thecoagulation pathway may be activated by a negatively charged surface such as dextran sulfate cellulose, resulting in the generation of bradykinin. Weinvestigated whether the increase in the generation of bradykinin during LDL adsorption is accompanied by the activation of endogenous production of nitric oxide (NO) in patients with peripheral atherosclerosis. LDL adsorption therapy was repeated ten times over a period of 3 months in ten peripheral atherosclerosis patients. Treatment significantly reduced serum total cholesterol and LDL cholesterol levels. This was associated with a significant improvement in Fontaine's classification and ankle pressure index. We also measured the kinin-kallikrein system and plasma levels of NO in the same patients. The results showed that coagulation factors of the intrinsic pathway including high-molecular-weight kininogen and prekallikrein decreased markedly after initial adsorption compared with the levels before treatment. There was a marked increase in bradykinin and NO concentrations after the initial adsorption, compared with their levels before adsorption. Our results suggest that the generation of bradykinin and increased plasma levels ofNO may contribute to the improvement in peripheral circulation after LDL adsorption in peripheral atherosclerosis patients. (C) 1998 Lippincote Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 02:35:41