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Titolo:
In vivo formation of IRF-1 homodimers
Autore:
Kirchhoff, S; Schaper, F; Oumard, A; Hauser, H;
Indirizzi:
GBF,aunschweig,nst Biotechnol, Dept Gene Regulat & Differentiat, D-38124 Br GBF Braunschweig Germany D-38124 Gene Regulat & Differentiat, D-38124 Br Rhein Westfal TH Aachen, Inst Biochem, D-52057 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-52057 , D-52057 Aachen, Germany
Titolo Testata:
BIOCHIMIE
fascicolo: 8-9, volume: 80, anno: 1998,
pagine: 659 - 664
SICI:
0300-9084(199808/09)80:8-9<659:IVFOIH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEQUENCE-BINDING-PROTEIN; INTERFERON REGULATORY FACTORS; TRANSCRIPTION FACTOR IRF-1; CELL-GROWTH INHIBITION; FACTOR-I IRF-1; NF-KAPPA-B; GENE-EXPRESSION; INDUCIBLE GENES; FACTOR FAMILY; IFN;
Keywords:
interferon regulatory factor 1; transcriptional activators; homodimerization; DNA-binding;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hauser, H GBF,rNatl Res Inst Biotechnol, Dept Gene Regulat & Differentiat,Mascherode GBF Mascheroder Weg 1 Braunschweig Germany D-38124 , Mascherode
Citazione:
S. Kirchhoff et al., "In vivo formation of IRF-1 homodimers", BIOCHIMIE, 80(8-9), 1998, pp. 659-664

Abstract

Interferon regulatory factor 1 (IRF-1) is a transcriptional activator which exerts different biological activities. IRF-1 activates interferon induced genes as well as genes which are not directly Linked to the interferon system, such as the ICE protease gene. IRF-1 activity is post-transcriptionally regulated in addition to transcriptional regulation by interferons, cytokines, hormones and many other factors. This includes heterodimerisation with activators and repressors of transcription. These protein interactions modulate the transactivating capacity of IRF-1. By using a two-hybrid system, we demonstrate that IRF-1 forms homodimers in vivo. The homodimerization domain was determined to be located in the N-terminal part of IRF-1 which belongs to the DNA-binding domain. Since this sequence is highly conserved between members of the IRF-family, our observation raises the question of homodimerization of other IRFs through this domain. (C) Societe francaise de biochimie et biologie moleculaire/Elsevier, Paris.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 03:48:42