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Titolo:
Prolonged exercise causes an increase in endothelin-1 production in the heart in rats
Autore:
Maeda, S; Miyauchi, T; Sakai, S; Kobayashi, T; Iemitsu, M; Goto, K; Sugishita, Y; Matsuda, M;
Indirizzi:
Univakaukuba, Inst Clin Med, Dept Internal Med, Div Cardiovasc, Ibaraki, Os Univ Tsukuba Ibaraki Osaka Japan 3058575 Med, Div Cardiovasc, Ibaraki, Os Univ5,sukuba, Inst Hlth & Sport Sci, Dept Sports Med, Ibaraki, Osaka 305857 Univ Tsukuba Ibaraki Osaka Japan 3058575 ports Med, Ibaraki, Osaka 305857 Univ,Tsukuba, Inst Hlth & Sport Sci, Dept Pharmacol, Ibaraki, Osaka 3058575 Univ Tsukuba Ibaraki Osaka Japan 3058575 harmacol, Ibaraki, Osaka 3058575 Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Ibaraki, Osaka 3050006, Japan Univ Tsukuba Ibaraki Osaka Japan 3050006 e, Ibaraki, Osaka 3050006, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 6, volume: 44, anno: 1998,
pagine: H2105 - H2112
SICI:
0363-6135(199812)44:6<H2105:PECAII>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOCONSTRICTOR PEPTIDE; PLASMA ENDOTHELIN-1; ENDOGENOUS ENDOTHELIN-1; BLOOD-FLOW; HYPERTROPHY; MECHANISM; RECEPTOR; CELLS; EXPRESSION; STRESS;
Keywords:
myocardial endothelin-1; positive inotropy; treadmill running; endothelin-converting enzyme; endothelin type A receptor; endothelin type B receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Miyauchi, T Univakaukuba, Inst Clin Med, Dept Internal Med, Div Cardiovasc, Ibaraki, Os Univ Tsukuba Ibaraki Osaka Japan 3058575 diovasc, Ibaraki, Os
Citazione:
S. Maeda et al., "Prolonged exercise causes an increase in endothelin-1 production in the heart in rats", AM J P-HEAR, 44(6), 1998, pp. H2105-H2112

Abstract

Cardiac myocytes produce endothelin-1 (ET-1). ET-1 has potent positive inotropic and chronotropic effects. We investigated whether production of ET-1in the heart is altered by prolonged exercise in rats. Rats ran on a treadmill for 45 min. Immediately after this exercise the heart and lungs were quickly removed. Control rats remained at rest during this 45-min period. Expression of preproET-1 mRNA in the heart was markedly higher in the exercised than in the control rats. The peptide level of ET-1 in the heart was also markedly higher in the exercised rats. Expression of endothelin type A- and type B-receptor mRNA and endothelin-converting enzyme mRNA in the heart did not differ between the groups. The peptide level of ET-1 and the preproET-1 mRNA level in the lungs of the exercised rats did not differ from those in the control rats. The present results show that production of ET-1 is markedly increased tissue specifically in the heart by exercise without appreciable changes in endothelin-converting enzyme and endothelin receptor expression. The present study suggests that myocardial ET-1 may participate in modulation of cardiac function during exercise.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/06/20 alle ore 23:57:40