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Titolo:
Expression of E-cadherin and alpha-catenin in patients with colorectal carcinoma - Correlation with cancer invasion and metastasis
Autore:
Gofuku, J; Shiozaki, H; Tsujinaka, T; Inoue, M; Tamura, S; Doki, Y; Matsui, S; Tsukita, S; Kikkawa, N; Monden, M;
Indirizzi:
Osaka Univ, Sch Med, Dept Surg 2, Osaka 5650871, Japan Osaka Univ Osaka Japan 5650871 ch Med, Dept Surg 2, Osaka 5650871, Japan Kyoto Univ, Fac Med, Dept Cell Biol, Kyoto, Japan Kyoto Univ Kyoto Japan yoto Univ, Fac Med, Dept Cell Biol, Kyoto, Japan Osaka Natl Hosp, Dept Surg, Osaka, Japan Osaka Natl Hosp Osaka JapanOsaka Natl Hosp, Dept Surg, Osaka, Japan
Titolo Testata:
AJCP. American journal of clinical pathology
fascicolo: 1, volume: 111, anno: 1999,
pagine: 29 - 37
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; EPIDERMAL GROWTH-FACTOR; HUMAN ESOPHAGEAL CANCER; LYMPH-NODE METASTASIS; HUMAN GASTRIC-CANCER; TYROSINE PHOSPHORYLATION; BETA-CATENIN; IMMUNOHISTOCHEMICAL EVALUATION; GENE-PRODUCT; ASSOCIATION;
Keywords:
colorectal cancer; alpha-catenin; immunohistochemistry; E-cadherin; cancer invasion; metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Gofuku, J Osaka Univ, Sch Med, Dept Surg 2, 2-2 Yamadaoka, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Osaka Japan 5650871 aka 5650871, Japan
Citazione:
J. Gofuku et al., "Expression of E-cadherin and alpha-catenin in patients with colorectal carcinoma - Correlation with cancer invasion and metastasis", AM J CLIN P, 111(1), 1999, pp. 29-37

Abstract

Cadherins form complexes with groups of cytoplasmic proteins, such as alpha-, beta-, and gamma-catenins, that link the cadherin molecule to the cytoskeleton. In this study, we conducted an immunohistochemical investigation of E-cadherin and alpha-catenin expression in 100 tissue samples obtained from colorectal cancer patients undergoing surgical treatment Reduced expression of alpha-catenin was observed in 56 (56%) of the cases and found to be significantly correlated with the depth of invasion of the patients' colorectal cancer and its metastasis to lymph nodes and liver In contrast, E-cadherin expression was reduced in 29 (29%) of the cases and was not significantly correlated with either depth of invasion or metastasis. Although the levels of expression of these proteins were positively correlated, coexpression pattern analysis showed that invasion and metastasis were correlated with a reduction of alpha-catenin expression regardless of the status of E-cadherin staining. Thus, to predict tumor invasion and metastasis in colorectal adenocarcinoma, it is useful to investigate not just the expression of E-cadherin but also the expression of alpha-catenin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:18:14