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Titolo:
Antiinflammatory actions of cat's claw: the role of NF-kappa B
Autore:
Sandoval-Chacon, M; Thompson, JH; Zhang, XJ; Liu, X; Mannick, EE; Sadowska-Krowicka, H; Charbonnet, RM; Clark, DA; Miller, MJS;
Indirizzi:
Louisiana State Univ, Med Ctr, Dept Paediat, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA Louisiana112ate Univ, Med Ctr, Stanley S Scott Canc Ctr, New Orleans, LA 70 Louisiana State Univ New Orleans LA USA 70112 anc Ctr, New Orleans, LA 70
Titolo Testata:
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
fascicolo: 12, volume: 12, anno: 1998,
pagine: 1279 - 1289
SICI:
0269-2813(199812)12:12<1279:AAOCCT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEROXYNITRITE-INDUCED APOPTOSIS; INTESTINAL EPITHELIAL-CELLS; INFLAMMATORY BOWEL-DISEASE; NITRIC-OXIDE SYNTHASE; UNCARIA-TOMENTOSA; OXINDOLE ALKALOIDS; 5-AMINOSALICYLIC ACID; ULCERATIVE-COLITIS; GENE-EXPRESSION; ZINC-METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Sandoval-Chacon, M Albany Med Coll, Dept Paediat, 47 New Scotland Ave, Albany, NY 12208 USA Albany Med Coll 47 New Scotland Ave Albany NY USA 12208
Citazione:
M. Sandoval-Chacon et al., "Antiinflammatory actions of cat's claw: the role of NF-kappa B", ALIM PHARM, 12(12), 1998, pp. 1279-1289

Abstract

Background: Uncaria tomentosa is a vine commonly known as cat's claw or 'u(n) over tilde a de gato' (UG) and is used in traditional Peruvian medicine for the treatment of a wide range of health problems, particularly digestive complaints and arthritis. Purpose: The aim of this study was to determine the proposed anti-inflammatory properties of cat's claw. Specifically: (i) does a bark extract of cat's claw protect against oxidant-induced stress in vitro, and (ii) to determine if UG modifies transcriptionally regulated events. Methods: Cell death was determined in two cell lines, RAW 264.7 and HT29 in response to peroxynitrite (PN, 300 mu m). Gene expression of inducible nitric oxide synthase (iNOS) in HT29 cells, direct effects on nitric oxide and peroxynitrite levels, and activation of NF-kappa B in RAW 264.7 cells as influenced by UG were assessed, Chronic intestinal inflammation was inducedin rats with indomethacin (7.5 mg/kg), with UG administered orally in the drinking water (5 mg/mL). Results: The administration of UG (100 mu g/mL) attenuated (P < 0.05) peroxynitrite-induced apoptosis in HT29 (epithelial) and RAW 264.7 cells (macrophage), Cat's claw inhibited lipopolysaccharide-induced iNOS gene expression, nitrite formation, cell death and inhibited the activation of NF-kappa B. Cat's claw markedly attenuated indomethacin-enteritis as evident by reduced myeloperoxidase activity, morphometric damage and liver metallothionein expression. Conclusions: Cat's claw protects cells against oxidative stress and negated the activation of NF-kappa B. These studies provide a mechanistic evidence for the widely held belief that cat's claw is an effective anti-inflammatory agent.

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Documento generato il 02/12/20 alle ore 17:42:02